Pubblicazioni – Marco Onorati

Editorial: Molecular and cellular logic of cerebral cortex development, evolution, and disease.

Dell’Anno MT, Conti L, Onorati M.

Front Neuroanat. 2023 Jul 7;17:1242684. doi: 10.3389/fnana.2023.1242684.

Inhibiting immunoregulatory amidase NAAA blocks ZIKV maturation in Human Neural Stem Cells.

Lai M, La Rocca V, Iacono E, Filipponi C, De Carli A, Favaro D, Fonnesu R, Filippini F, Spezia PG, Amato R, Catelli E, Matteo B, Lottini G, Onorati M, Clementi N, Freer G, Piomelli D, Pistello M.

Antiviral Res. 2023 Aug;216:105664. doi: 10.1016/j.antiviral.2023.105664.

Microcephaly-associated protein WDR62 shuttles from the Golgi apparatus to the spindle poles in human neural progenitors.

Dell’Amico C, Angulo Salavarria MM, Takeo Y, Saotome I, Dell’Anno MT, Galimberti M, Pellegrino E, Cattaneo E, Louvi A, Onorati M.

Elife. 2023 Jun 5;12:e81716. doi: 10.7554/eLife.81716.

Low Forces Push the Maturation of Neural Precursors into Neurons.

De Vincentiis S, Baggiani M, Merighi F, Cappello V, Lopane J, Di Caprio M, Costa M, Mainardi M, Onorati M, Raffa V.

Small. 2023 Apr 14:e2205871. doi: 10.1002/smll.202205871.

Cortico-thalamic development and disease: From cells, to circuits, to schizophrenia.
Angulo Salavarria MM, Dell’Amico C, D’Agostino A, Conti L, Onorati M.
Front Neuroanat. 2023 Mar 2;17:1130797. doi: 10.3389/fnana.2023.1130797.

Zika virus induces FOXG1 nuclear displacement and downregulation in human neural progenitors.

Lottini G, Baggiani M, Chesi G, D’Orsi B, Quaranta P, Lai M, Pancrazi L, Onorati M, Pistello M, Freer G, Costa M.
Stem Cell Reports. 2022 Jul 12;17(7):1683-1698. doi: 10.1016/j.stemcr.2022.05.008

Centrin 2: A Novel Marker of Mature and Neoplastic Human Astrocytes.
Degl’Innocenti E, Poloni TE, Medici V, Recupero L, Dell’Amico C, Vannini E, Borello U, Mazzanti CM, Onorati M, Dell’Anno MT.
Front Cell Neurosci. 2022 Apr 29;16:858347. doi: 10.3389/fncel.2022.858347.

ASCL1 phosphorylation and ID2 upregulation are roadblocks to glioblastoma stem cell differentiation.
Azzarelli R, McNally A, Dell’Amico C, Onorati M, Simons B, Philpott A.
Sci Rep. 2022 Feb 11;12(1):2341. doi: 10.1038/s41598-022-06248-x.

Genome editing in stem cells for genetic neurodisorders.
Dell’ Amico, C., Tata, A., Pellegrino, E., Onorati, M., Conti, L.
Progress in Molecular Biology and Translational Science. DOI: 10.1016/bs.pmbts.2020.12.006.

Activity of the SNARE Protein SNAP29 at the Endoplasmic Reticulum and Golgi Apparatus.

Morelli E, Speranza EA, Pellegrino E, Beznoussenko GV, Carminati F, Garré M, Mironov AA, Onorati M, Vaccari T.

Front Cell Dev Biol. 2021 Feb 18;9:637565. doi: 10.3389/fcell.2021.637565.

Human Neural Stem Cell Systems to Explore Pathogen-Related Neurodevelopmental and Neurodegenerative Disorders.
Baggiani M, Dell’Anno MT, Pistello M, Conti L, Onorati M.
Cells. 2020 Aug 12;9(8):1893. doi: 10.3390/cells9081893.

Dynamic and Cell-Specific DACH1 Expression in Human Neocortical and Striatal Development.
Castiglioni V, Faedo A, Onorati M, Bocchi VD, Li Z, Iennaco R, Vuono R, Bulfamante GP, Muzio L, Martino G, Sestan N, Barker RA, Cattaneo E.
Cereb Cortex. 2019 May 1;29(5):2115-2124. doi: 10.1093/cercor/bhy092.

Integrative functional genomic analysis of human brain development and neuropsychiatric risks.
Li M, Santpere G, Imamura Kawasawa Y, Evgrafov OV, Gulden FO, Pochareddy S, Sunkin SM, Li Z, Shin Y, Zhu Y, Sousa AMM, Werling DM, Kitchen RR, Kang HJ, Pletikos M, Choi J, Muchnik S, Xu X, Wang D, Lorente-Galdos B, Liu S, Giusti-Rodríguez P, Won H, de Leeuw CA, Pardiñas AF; BrainSpan Consortium; PsychENCODE Consortium; PsychENCODE Developmental Subgroup (…Onorati M…), Hu M, Jin F, Li Y, Owen MJ, O’Donovan MC, Walters JTR, Posthuma D, Levitt P, Weinberger DR, Hyde TM, Kleinman JE, Geschwind DH, Hawrylycz MJ, State MW, Sanders SJ, Sullivan PF, Gerstein MB, Lein ES, Knowles JA, Sestan N.
Science. 2018 Dec 14;362(6420). pii: eaat7615. doi: 10.1126/science.aat7615. PMID:30545854

Human neuroepithelial stem cell regional specificity enables spinal cord repair through a relay circuit.
Dell’Anno MT, Wang X, Onorati M, Li M, Talpo F, Sekine Y, Ma S, Liu F, Cafferty WBJ, Sestan N, Strittmatter SM.
Nat Commun. 2018 Aug 24;9(1):3419. doi: 10.1038/s41467-018-05844-8. PMID: 30143638

Molecular and cellular reorganization of neural circuits in the human lineage.
Sousa AMM, Zhu Y, Raghanti MA, Kitchen RR, Onorati M, Tebbenkamp ATN, Stutz B, Meyer KA, Li M, Kawasawa YI, Liu F, Perez RG, Mele M, Carvalho T, Skarica M, Gulden FO, Pletikos M, Shibata A, Stephenson AR, Edler MK, Ely JJ, Elsworth JD, Horvath TL, Hof PR, Hyde TM, Kleinman JE, Weinberger DR, Reimers M, Lifton RP, Mane SM, Noonan JP, State MW, Lein ES, Knowles JA, Marques-Bonet T, Sherwood CC, Gerstein MB, Sestan N.
Science. 2017 Nov 24;358(6366):1027-1032. doi: 10.1126/science.aan3456. PMID:29170230

Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia.
Onorati M, Li Z, Liu F, Sousa AMM, Nakagawa N, Li M, Dell’Anno MT, Gulden FO, Pochareddy S, Tebbenkamp ATN, Han W, Pletikos M, Gao T, Zhu Y, Bichsel C, Varela L, Szigeti-Buck K, Lisgo S, Zhang Y, Testen A, Gao XB, Mlakar J, Popovic M, Flamand M, Strittmatter SM, Kaczmarek LK, Anton ES, Horvath TL, Lindenbach BD, Sestan N.
Cell Rep. 2016 Sep 6;16(10):2576-2592. doi: 10.1016/j.celrep.2016.08.038. Epub 2016 Aug 24. PMID:27568284

Hmga2 is required for neural crest cell specification in Xenopus laevis.
Macrì S, Simula L, Pellarin I, Pegoraro S, Onorati M, Sgarra R, Manfioletti G, Vignali R.
Dev Biol. 2016 Mar 1;411(1):25-37. doi: 10.1016/j.ydbio.2016.01.014. Epub 2016 Jan 22.PMID:26806704

Molecular and functional definition of the developing human striatum.
Onorati M, Castiglioni V, Biasci D, Cesana E, Menon R, Vuono R, Talpo F, Laguna Goya R, Lyons PA, Bulfamante GP, Muzio L, Martino G, Toselli M, Farina C, Barker RA, Biella G, Cattaneo E.
Nat Neurosci. 2014 Dec;17(12):1804-15. doi: 10.1038/nn.3860. Epub 2014 Nov 10. PMID:25383901

iPSC-derived neural precursors exert a neuroprotective role in immune-mediated demyelination via the secretion of LIF.
Laterza C, Merlini A, De Feo D, Ruffini F, Menon R, Onorati M, Fredrickx E, Muzio L, Lombardo A, Comi G, Quattrini A, Taveggia C, Farina C, Cattaneo E, Martino G.
Nat Commun. 2013;4:2597. doi: 10.1038/ncomms3597.PMID:24169527

Expression and functional characterization of Xhmg-at-hook genes in Xenopus laevis.
Macrì S, Sgarra R, Ros G, Maurizio E, Zammitti S, Milani O, Onorati M, Vignali R, Manfioletti G.
PLoS One. 2013 Jul 25;8(7):e69866. doi: 10.1371/journal.pone.0069866. Print 2013. PMID:23936116

Human pluripotent stem cell differentiation into authentic striatal projection neurons.
Delli Carri A, Onorati M, Castiglioni V, Faedo A, Camnasio S, Toselli M, Biella G, Cattaneo E.
Stem Cell Rev. 2013 Aug;9(4):461-74. doi: 10.1007/s12015-013-9441-8.PMID:23625190

EZ spheres: a stable and expandable culture system for the generation of pre-rosette multipotent stem cells from human ESCs and iPSCs.
Ebert AD, Shelley BC, Hurley AM, Onorati M, Castiglioni V, Patitucci TN, Svendsen SP, Mattis VB, McGivern JV, Schwab AJ, Sareen D, Kim HW, Cattaneo E, Svendsen CN.
Stem Cell Res. 2013 May;10(3):417-427. doi: 10.1016/j.scr.2013.01.009. Epub 2013 Feb 4. PMID:23474892

Developmentally coordinated extrinsic signals drive human pluripotent stem cell differentiation toward authentic DARPP-32+ medium-sized spiny neurons.
Delli Carri A, Onorati M, Lelos MJ, Castiglioni V, Faedo A, Menon R, Camnasio S, Vuono R, Spaiardi P, Talpo F, Toselli M, Martino G, Barker RA, Dunnett SB, Biella G, Cattaneo E.
Development. 2013 Jan 15;140(2):301-12. doi: 10.1242/dev.084608. PMID:23250204

Creation of an open-access, mutation-defined fibroblast resource for neurological disease research.
Wray S, Self M, NINDS Parkinson’s Disease iPSC Consortium, NINDS Huntington’s Disease iPSC Consortium*, NINDS ALS iPSC Consortium, et al. (*: Gusella JF, MacDonald ME, Wheeler VC, Ross CA, Akimov S, Arjomand J, Thompson LM, King A, Hermanowicz N, Winokur S, Svendsen CN, Mattis V, Onorati M, Cattaneo E, Allen ND, Kemp PJ, Kim KS, Finkbeiner S).
PLoS One. 2012;7(8):e43099. doi: 10.1371/journal.pone.0043099. Epub 2012 Aug 27. PMID:22952635

Induced pluripotent stem cells from patients with Huntington’s disease show CAG-repeat-expansion-associated phenotypes.
HD iPSC Consortium. Mattis VB, Ebert A, Svendsen SP, Svendsen CN, King A, Casale M, Winokur ST, Batugedara G, Vawter M, Donovan PJ, Lock LF, Thompson LM, Zhu Y, Fossale E, Singh R, Gillis T, Mysore J, Li J, Seong I, Shen Y, Chen X, Wheeler V, MacDonald ME, Gusella JF, Akimov S, Arbez N, Juoppen T, Ratoviski T, Chiang JH,. Kim WR, Chighladze E, Watkin E, Zhong C, Makri G, Cole RN, Margolis RL, Song H, Ming G, Ross CA, Kaye JA, Daub A, Sharma P, Mason AR, Finkbeiner S, Yu J, Thomson JA, Rushton D, Brazier SP, Battersby AA, Redfern A, Tseng H, Harrison AW, Kemp PJ, Allen ND, Onorati M, Castiglioni V, Cattaneo E, Arjomand J, Svendsen C.
Cell Stem Cell. 2012 Aug 3;11(2):264-78. doi: 10.1016/j.stem.2012.04.027. Epub 2012 Jun 28. PMID: 22748968

Induced pluripotent stem cell lines from Huntington’s disease mice undergo neuronal differentiation while showing alterations in the lysosomal pathway.
Castiglioni V, Onorati M, Rochon C, Cattaneo E.
Neurobiol Dis. 2012 Apr;46(1):30-40. doi: 10.1016/j.nbd.2011.12.032. Epub 2011 Dec 28. PMID:22227000

Preservation of positional identity in fetus-derived neural stem (NS) cells from different mouse central nervous system compartments.
Onorati M, Binetti M, Conti L, Camnasio S, Calabrese G, Albieri I, Di Febo F, Toselli M, Biella G, Martynoga B, Guillemot F, Consalez GG, Cattaneo E.
Cell Mol Life Sci. 2011 May;68(10):1769-83. doi: 10.1007/s00018-010-0548-7. Epub 2010 Oct 28. Erratum in: Cell Mol Life Sci. 2016 Aug;73(16):3217-9. PMID:20981563

A DNA transposon-based approach to functional screening in neural stem cells.
Albieri I, Onorati M, Calabrese G, Moiana A, Biasci D, Badaloni A, Camnasio S, Spiliotopoulos D, Ivics Z, Cattaneo E, Consalez GG.
J Biotechnol. 2010 Oct 1;150(1):11-21. doi: 10.1016/j.jbiotec.2010.07.027. Epub 2010 Aug 3. PMID: 20688113

Neuropotent self-renewing neural stem (NS) cells derived from mouse induced pluripotent stem (iPS) cells.
Onorati M, Camnasio S, Binetti M, Jung CB, Moretti A, Cattaneo E.
Mol Cell Neurosci. 2010 Mar;43(3):287-95. doi: 10.1016/j.mcn.2009.12.002. Epub 2009 Dec 21. PMID:20026276

A specific box switches the cell fate determining activity of XOTX2 and XOTX5b in the Xenopus retina.
Onorati M, Cremisi F, Liu Y, He RQ, Barsacchi G, Vignali R.
Neural Dev. 2007 Jun 27;2:12.PMID:17597530

Identification and developmental expression of Xenopus hmga2beta.
Benini F, Onorati M, Altamura S, Manfioletti G, Vignali R.
Biochem Biophys Res Commun. 2006 Dec 15;351(2):392-7. Epub 2006 Oct 23. PMID:17070502