MARVENE (magnetic nanoparticles for nerve regeneration)

The aim of MARVENE project is to the use magnetic nanoparticles (MNPs) as functional nano-structures to enhance nerve regeneration by exploiting the mechanical forces acting on MNP-neurons to promote axonal elongation/growth.

Application of a tensile force to a neuron or an axon can stimulate neurite initiation or axon elongation in the desired direction. MNPs can be used to generate these tensile forces and manipulate axons to elongate, to overcome inhibitory substrates, and to enhance the trophic signalling of axon growth by the functionalization with biological molecules e.g., neural binders and neurotrophic factors.


Prof. Gerardo Goya, Istituto de nanosciencia de Aragon, Spain

Prof. Gerburg Keilhoff, Institute of Medical Neurobiology, University of Magdeburg, Germany

Dr. Lijung Wang, Institute for medical science and technology, United Kingdom


  • Martina Giannaccini, M. Pilar Calatayud, Andrea Poggetti, Silvia Corbianco, Michela Novelli, Melania Paoli, Pietro Battistini, Maura Castagna, Luciana Dente, Paolo Parchi, Michele Lisanti, Gabriella Cavallini, Concepción Junquera, Gerardo F. Goya, Vittoria Raffa, Magnetic Nanoparticles for Efficient Delivery of Growth Factors: Stimulation of Peripheral Nerve Regeneration, 2017 Advanced Helthcare Materials 6(7):1601429. IF: 5.76
  • Pinkernelle J, Raffa V, Calatayud MP, Goya GF, Riggio C, Keilhoff G. Growth factor choice is critical for successful functionalization of nanoparticles. Front Neurosci. (2015) 2;9:305. IF:3.656
  • Wang, L., Min, Y., Wang, Z., (…), Raffa, V., Goya, G.F., Keilhoff, G., Cuschieri, A. (2015) Evaluation of In-Situ magnetic signals from iron oxide nanoparticle-labeled PC12 cells by atomic force microscopy . Journal of Biomedical Nanotechnology 11, 457-468. IF: 7.58
  • Goya, G.F., Calatayud, M.P., Sanz, B., (…), Raffa, V., Torres, T.E., Ibarra, M.R (2014) Magnetic nanoparticles for magnetically guided therapies against neural diseases. MRS Bulletin 39 (11), pp. 965-96911 (3), pp. 457-468. IF: 5.069
  • Calatayud P, Sanz B, Raffa V, Riggio C, Ibarra M R, Goya G F. The effect of surface charge of functionalized Fe3O4 nanoparticles on protein adsorption and cell uptake. Biomaterials, 35(24):6389-99, IF: 7.604
  • Riggio C, Calatayud M P, Giannaccini M, Sanz B, Torres T E, Fernandez-Pacheco R, Ripoli A, Ibarra M R, Dente L, Cuschieri A, Goya G F, Raffa V. The orientation of the neuronal growth process can be directed via magnetic nanoparticles under an applied magnetic field (2014) NANOMEDICINE (ISSN:1549-9634), p. S1549-9634 Vol13, IF: 6.692
  • Riggio C , Nocentini S, Catalayud MP, Goya GF, Cuschieri A, Raffa V, del Río JA. (2013). Generation of magnetized olfactory ensheathing cells for regenerative studies in the central and peripheral nervous tissue. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (ISSN:1422-0067) p. 10852 – 10868 Vol. 14, IF: 2.464
  • Calatayud M.P., Riggio C., Raffa V., Sanz B., Torres T.E., Ibarra M.R., Hoskins C., Cuschieri A., Wang L., Pinkernelle J., Keilhoff G., Goya G.F. (2013). Neuronal cells loaded with PEI-coated Fe3O4 nanoparticles for magnetically guided nerve regeneration. JOURNAL OF MATERIALS CHEMISTRY. B (ISSN:2050-7518) p. 3607 – 3616 Vol. 1, IF: 6.108
  • Riggio C; Calatayud M P; Hoskins C; Pinkernelle J; Sanz B; Torres T E; Ibarra M R; Wang L; Keilhoff G; Goya G F; Raffa V; Cuschieri A (2012). Poly-l-lysine-coated magnetic nanoparticles as intracellular actuators for neural guidance. INTERNATIONAL JOURNAL OF NANOMEDICINE (ISSN:1176-9114) p. 3155 – 3166 Vol. 7, IF: 3.130