Precision micro- and nanotools for innovative pharmacotherapies, with a focus on development of stimuli responsive drug-delivery systems
- Development of targeting strategies for the synthesis of bioactive entities able to selectively recognize specific biomarkers, including biodegradable polymeric drug nanocarriers.
- Development of smart biomaterials for the production of injectable or printable drug delivery systems with “programmed” and “on-demand” release, able to convert an external remote stimulus (visible light or NIR laser irradiation) into physicochemical perturbation of the bulk material that will be exploited to tailor or enable the release of active molecules or to activate a physiological cascade of events that favors the restoration of physiological functions.
Bachelor and Master Thesis Projects
- Nanovesciles and polymeric nanoparticles as drug delivery systems
- Host/Guest Cyclodextrins (CDs) complexes in pharmaceutical technology: formulation, chemical derivatization of CDs, and NMR studies
- Metal-based anticancer complexes: NMR interaction studies with target protein or other relevant biological entities
- NMR Chemosensing with inorganic/hybrid nanoparticles
Any other projects proposed by the student to be investigated mainly by liquid-state NMR spectroscopy are warmly welcomed.
For other questions feel free to contact andrea.cesari@unipi.it