Publications

1. Poli G, Martinelli Tuccinardi T. A, “Reliability analysis and optimization of the consensus docking approach for the development of virtual screening studies” J Enzyme Inhib Med Chem. 2016 ASAP.
2. Petrou A, Geronikaki A, Terzi E, Ozensoy Guler O, Tuccinardi T, Supuran CT. “Inhibition of carbonic anhydrase isoforms I, II, IX and XII with secondary sulfonamides incorporating benzothiazole scaffolds” J Enzyme Inhib Med Chem. 2016 ASAP.
3. Poli G, Gelain A, Porta F, Asai A, Martinelli A, Tuccinardi T. “Identification of a new STAT3 dimerization inhibitor through a pharmacophore-based virtual screening approach” J Enzyme Inhib Med Chem. 2016 ASAP.
4. Tuccinardi T, Poli G, Corchia I, Granchi C, Lapillo M, Macchia M, Minutolo F, Ortore G, Martinelli A. “A Virtual Screening Study for Lactate Dehydrogenase 5 Inhibitors by using a Pharmacophore-Based Approach” Mol. Inf. 2016 ASAP.
5. Granchi C, Lapillo M, Russo Spena C, Rizzolio F, Tuccinardi T, Martin TA, Carlson KE, Katzenellenbogen JA, Minutolo F. “Cyclic-ketoximes as ER beta-selective agonists” ChemMedChem 2016 ASAP.
6. Kumar S, Ceruso M, Tuccinardi T, Supuran CT, Sharma PK. “Pyrazolylbenzo[d]imidazoles as new potent and selective inhibitors of carbonic anhydrase isoforms hCA IX and XII” Bioorg Med Chem 201624(13):2907-29013.
7. Tabrizi MA, Baraldi PG, Ruggiero E, Saponaro G, Baraldi S, Poli G, Tuccinardi T, Ravani A, Vincenzi F, Borea PA, Varani K. “Synthesis and Structure Activity Relationship Investigation of Triazolo[1,5-a]pyrimidines as CB2 Cannabinoid Receptor Inverse Agonists” Eur J Med Chem. 2016 113:11-27.
8. Camodeca C, Nuti E, Tepshi L, Boero S, Tuccinardi T, Stura EA, Poggi A, Zocchi MR, Rossello A. “Discovery of a new selective inhibitor of A Disintegrin And Metalloprotease 10 (ADAM-10) able to reduce the shedding of NKG2D ligands in Hodgkin’s lymphoma cell models” Eur J Med Chem. 2016 111:193-201.
9. Granchi C, Rizzolio F, Bordoni V, Caligiuri I, Manera C, Macchia M, Minutolo F, Martinelli A, Giordano A, Tuccinardi T. “4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors” J Enzyme Inhib Med Chem. 2016 31(1):137-146.
10. Granchi C, Qian Y, Yeon Lee H, Paterni I, Pasero C, Iegre J, Carlson KE, Tuccinardi T, Chen X, Katzenellenbogen JA, Hergenrother PJ, Minutolo FM. “Salicylketoximes That Target Glucose Transporter 1 Restrict Energy Supply to Lung Cancer Cells” ChemMedChem. 2015 10(11):1892-1900.
11. Nuti E, Cantelmo AR, Gallo C, Bruno A, Bassani B, Camodeca C, Tuccinardi T, Vera L, Orlandini E, Nencetti S, Stura EA, Martinelli A, Dive V, Albini A, Rossello A. “N-O-Isopropyl Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors: Hit Selection and in vivo Antiangiogenic Activity” J Med Chem. 2015 58(18):7224-7240.
12. Tuccinardi T, Poli G, dell’Agnello M, Granchi C, Minutolo F, Martinelli A. “Receptor-based virtual screening evaluation for the identification of estrogen receptor β ligands” J Enzyme Inhib Med Chem. 2015 30(4):662-670.
13. Krasavin M, Korsakov M, Dorogov M, Tuccinardi T, Dedeoglu N, Supuran CT. “Probing the ‘bipolar’ nature of the carbonic anhydrase active site: aromatic sulfonamides containing 1,3-oxazol-5-yl moiety as picomolar inhibitors of cytosolic CA I and CA II isoforms” Eur J Med Chem. 2015 101:334-347.
14. Nassini R, Fusi C, Materazzi S, Coppi E, Tuccinardi T, Marone IM, De Logu F, Preti D, Tonello R, Chiarugi A, Patacchini R, Geppetti P, Benemei S. “The TRPA1 channel mediates the analgesic action of dipyrone and pyrazolone derivatives” Br J Pharmacol. 2015 172(13):3397-3411.
15. Tintori C, La Sala G, Vignaroli G, Botta L, Fallacara AL, Falchi F, Radi M, Zamperini C, Dreassi E, Dello Iacono L, Orioli D, Biamonti G, Garbelli M, Lossani A, Gasparrini F, Tuccinardi T, Laurenzana I, Angelucci A, Maga G, Schenone S, Brullo C, Musumeci F, Desogus A, Crespan E, Botta M. “Studies on the ATP binding site of Fyn kinase for the identification of new inhibitors and their evaluation as potential agents against tauopathies and tumors.” J Med Chem. 2015 58(11):4590-4609.
16. Bader A, Tuccinardi T, Granchi C, Martinelli A, Macchia M, Minutolo F, De Tommasi N, Braca A. “Phenylpropanoids and Flavonoids from Phlomis kurdica as Inhibitors of Human Lactate Dehydrogenase” Phytochem. 2015 116:262-268.
17. Tabrizi MA, Baraldi PG, Ruggiero E, Saponaro G, Baraldi S, Romagnoli R, Martinelli A, Tuccinardi T. “Pyrazole phenylcyclohexylcarbamates as inhibitors of human fatty acid amide hydrolases (FAAH)” Eur J Med Chem. 2015 97:289-305.
18. Granchi C, Capecchi A, Del Frate G, Martinelli A, Macchia M, Minutolo F, Tuccinardi T. “Development and Validation of a Docking-Based Virtual Screening Platform for the Identification of New Lactate Dehydrogenase Inhibitors” Molecules. 2015, 20(5):8772-8790.
19. Poli G, Giuntini N, Martinelli A, Tuccinardi T. “Application of a FLAP-Consensus Docking Mixed Strategy for the Identification of New FAAH Inhibitors” J Chem Inf Model. 2015 55(3):667-675.
20. Di BussoloV, Calvaresi EC, Granchi C, Del Bino L, Frau I, Dasso Lang MC, Tuccinardi T, Macchia M, Martinelli A, Hergenrother PJ, Minutolo F. “Synthesis and biological evaluation of non-glucose glycoconjugated N-hydroyxindole class LDH inhibitors as anticancer agents”. RSC Adv. 2015, 5(26): 19944-19954.
21. Paterni I, Bertini S, Granchi C, Tuccinardi T, Macchia M, Martinelli A, Caligiuri I, Toffoli G, Rizzolio F, Carlson KE, Katzenellenbogen BS, Katzenellenbogen JA, Minutolo F. “Highly selective salicylketoxime-based estrogen receptor beta agonists display antiproliferative activities in a glioma model.” J Med Chem. 2015, 58(3):1184–1194.
22. Enyedy EA, Dömötör O, Bali K, Hetényi A, Tuccinardi T, Keppler BK. “Interaction of the anticancer gallium(III) complexes of 8-hydroxyquinoline and maltol with human serum proteins.” J Biol Inorg Chem. 2015, 20(1):77-88.
23. Fusi C, Materazzi S, Benemei S, Coppi E, Trevisan G, Marone I, Minocci D, De Logu F, Tuccinardi T, Di Tommaso M, Susini T, Moneti G, Pieraccini G, Geppetti P, Nassini R. “Steroidal and non-steroidal third-generation aromatase inhibitors induce pain-like symptoms via TRPA1.” Nature Communications 2014, 5:5736.
24. Tuccinardi T, Poli G, Romboli V, Giordano A, Martinelli A. “Extensive consensus docking evaluation for ligand pose prediction and virtual screening studies” J Chem Inf Model. 2014, 54(10):2980-2986.
25. Poli G, Martinelli A, Tuccinardi T. “Computational Approaches for the Identification and Optimization of Src Family Kinases Inhibitors.” Curr Med Chem. 2014, 21(28):3281-3293.
26. Tuccinardi T, Granchi C, Rizzolio F, Caligiuri I, Battistello V, Toffoli G, Minutolo F, Macchia M, Martinelli A. “Identification and characterization of a new reversible MAGL inhibitor” Bioorg Med Chem. 2014, 22(13):3285-3291.
27. Wong CH, Nguyen L, Peh J, Luu LM, Sanchez JS, Richardson SL, Tuccinardi T, Tsoi H, Chan WY, Chan HY, Baranger AM, Hergenrother PJ, Zimmerman SC. “Targeting Toxic RNAs that Cause Myotonic Dystrophy Type 1 (DM1) with a Bisamidinium Inhibitor.” J Am Chem Soc. 2014, 136(17):6355-6361.
28. Digilio G, Tuccinardi T, Casalini F, Cassino C, Dias DM, Geraldes CFGC, Catanzaro V, Maiocchi A, Rossello A. “Study of the binding interaction between fluorinated Matrix Metalloproteinase inhibitors and Human Serum Albumin.” Eur J Med Chem. 2014, 79:13-23.
29. Dömötör O, Tuccinardi T, Karcz D, Walsh M, Creaven BS, Enyedy E. “Interaction of anticancer reduced Schiff base coumarin derivatives with human serum albumin investigated by fluorescence quenching and molecular modeling” Bioorg Chem. 2014, 52:16-23.
30. Malfitano AM, Laezza C, Saccomanni G, Tuccinardi T, Manera C, Martinelli A, Ciaglia E, Pisanti S, Vitale M, Gazzerro P, Bifulco M. “Immune-Modulation and Properties of Absorption and Blood Brain Barrier Permeability of 1,8-Naphthyridine Derivatives.” J Neuroimmune Pharmacol. 2013, 8(5):1077-1086.
31. Tuccinardi T, Granchi C, Iegre J, Paterni I, Bertini S, Macchia M, Martinelli A, Qian Y, Chen X, Minutolo F. “Oxime-based inhibitors of glucose transporter 1 displaying antiproliferative effects in cancer cells.” Bioorg Med Chem. Lett. 2013, 23(24):6923-6927.
32. Calvaresi EC, Granchi C, Tuccinardi T, Di Bussolo V, Huigens III RW, Lee HY, Palchaudhuri R, Macchia M, Martinelli A, Minutolo F, Hergenrother PJ. “Dual Targeting of the Warburg Effect with a Glucose-Conjugated Lactate Dehydrogenase Inhibitor” Chembiochem. 2013, 14(17):2263-2267.
33. Poli G, Tuccinardi T, Rizzolio F, Caligiuri I, Botta L, Granchi C, Ortore G, Minutolo F, Schenone S, Martinelli A. “Identification of new FYN kinase inhibitors using a FLAP-based approach.” J Chem Inf Model. 2013, 53(10):2538-2547.
34. Granchi C, Calvaresi EC, Tuccinardi T, Paterni I, Macchia M, Martinelli A, Hergenrother PJ, Minutolo F. “Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2- carboxylate (NHI) and malonic (Mal) scaffolds.” Org Biomol Chem. 2013, 11(38):6588-6596.
35. Aghazadeh Tabrizi M, Baraldi PG, Saponaro G, Moorman A, Romagnoli R, Preti D, Baraldi S, Ruggiero E, Tintori C, Tuccinardi T, Vincenzi F, Borea PA, Varani K. “Discovery of 7-Oxo-pyrazolo[1,5-a]pyrimidine-6-carboxamides as Potent and Selective CB2 Cannabinoid Receptor Inverse Agonists.” J Med Chem. 2013, 56(11):4482-4496.
36. Malfitano AM, Laezza C, D’Alessandro A, Procaccini C, Saccomanni G, Tuccinardi T, Manera C, Macchia M, Matarese G, Gazzerro P, Bifulco M. “Effects on Immune Cells of a New 1,8-Naphthyridin-2-One Derivative and Its Analogues as Selective CB2 Agonists: Implications in Multiple Sclerosis” PLoS One. 2013 May 1;8(5):e62511.
37. Tuccinardi T, Bertini S, Granchi C, Ortore G, Macchia M, Minutolo F, Martinelli A, Supuran CT. “Salicylaldoxime derivatives as new leads for the development of Carbonic Anhydrase inhibitors” Bioorg Med Chem. 2013, 21(6):1511-1515.
38. Wong CH, Richardson SL, Ho YJ, Lucas AM, Tuccinardi T, Baranger AM, Zimmerman SC. “Investigating the Binding Mode of an Inhibitor of the MBNL1⋅RNA Complex in Myotonic Dystrophy Type 1 (DM1) Leads to the Unexpected Discovery of a DNA-Selective Binder.” Chembiochem. 2012, 13(17):2505-2509.
39. Manera C, Saccomanni G, Malfitano AM, Bertini S, Castelli F, Laezza C, Ligresti A, Lucchesi V, Tuccinardi T, Rizzolio F, Bifulco M, Di Marzo V, Giordano A, Macchia M, Martinelli A. “Rational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: An investigation of the 1,8-naphthyridin-2(1H)-one scaffold.” Eur J Med Chem. 2012, 52:284-294.
40. Ortore G, Tuccinardi T, Martinelli A. “Computational Studies on Translocator Protein (tspo) and its Ligands.” Curr Top Med Chem. 2012, 12(4):352-359.
41. Marques SM, Tuccinardi T, Nuti E, Santamaria S, André V, Rossello A, Martinelli A, Santos MA. “Novel 1-hydroxypiperazine-2,6-diones as new leads in the inhibition of metalloproteinases.” J Med Chem. 2011, 54(24):8289–8298.
42. Granchi C, Roy S, Mottinelli M, Nardini E, Campinoti F, Tuccinardi T, Lanza M, Betti L, Giannaccini G, Lucacchini A, Martinelli A, Macchia M, Minutolo F. Synthesis of sulfonamide-containing N-hydroxyindole-2-carboxylates as inhibitors of human lactate dehydrogenase-isoform 5. Bioorg Med Chem Lett. 2011, 21(24):7331-7336.
43. Granchi C, Roy S, De Simone A, Salvetti I, Tuccinardi T, Martinelli A, Macchia M, Lanza M, Betti L, Giannaccini G, Lucacchini A, Giovannetti E, Sciarrillo R, Peters GJ, Minutolo F. “N-Hydroxyindole-based inhibitors of lactate dehydrogenase against cancer cell proliferation.” Eur J Med Chem. 2011, 46(11):5398-5407.
44. Granchi C, Roy S, Del Fiandra C, Tuccinardi T, Lanza M, Betti L, Giannaccini G, Lucacchini A, Martinelli A, Macchia M, Minutolo F. “Triazole-substituted N-hydroxyindol-2-carboxylates as inhibitors of isoform 5 of human lactate dehydrogenase (hLDH5)” MedChemComm. 2011, 2(7), 638-643.
45. Enyedy EA, Horváth L, Hetényi A, Tuccinardi T, Hartinger CG, Keppler BK, Kiss T. “Interactions of the carrier ligands of antidiabetic metal complexes with human serum albumin: a combined spectroscopic and separation approach with molecular modeling studies” Bioorg Med Chem. 2011, 19(14):4202-4210.
46. Tuccinardi T, Martinelli A. Protein Kinase Homology Models: Recent Developments and Results. Curr Med Chem. 2011;18(19):2848-2853.
47. Carrasco MP, Enyedy EA, Krupenko NI, Krupenko SA, Nuti E, Tuccinardi T, Santamaria S, Rossello A, Martinelli A, Santos MA. “Novel Folate-Hydroxamate Based Antimetabolites: Synthesis and Biological Evaluation.” Med Chem. 2011, 7(4):265-274.
48. Tuccinardi T, Zizzari AT, Brullo C, Daniele S, Musumeci F, Schenone S, Trincavelli ML, Martini C, Martinelli A, Giorgi G, Botta M. “Substituted pyrazolo[3,4-b]pyridines as human A(1) adenosine antagonists: Developments in understanding the receptor stereoselectivity.” Org Biomol Chem. 2011, 9(12):4448-4455 (cover of the Volume).
49. Bertini S, De Cupertinis A, Granchi C, Bargagli B, Tuccinardi T, Martinelli A, Macchia M, Gunther JR, Carlson KE, Katzenellenbogen JA, Minutolo F. “Selective And Potent Agonists For Estrogen Receptor Beta Derived From Molecular Refinements Of Salicylaldoximes” Eur Med Chem. 2011, 46(6):2453-2462.
50. Granchi C, Roy S, Giacomelli C, Macchia M, Tuccinardi T, Martinelli A, Lanza M, Betti L, Giannaccini G, Lucacchini A, Funel N, León LG, Giovannetti E, Peters GJ, Palchaudhuri R, Calvaresi EC, Hergenrother PJ, Minutolo F. “Discovery of N-Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform A (LDH-A) as Starvation Agents against Cancer Cells.” J Med Chem. 2011, 54(6):1599-1612.
51. Bajorath J, Barreca ML, Bender A, Bryce R, Hutter M, Laggner C, Laughton C, Martin Y, Mitchell J, Padova A, Renner S, Selzer PM, Sherman W, Sippl W, Taft C, Tuccinardi T, Vistoli G, Willett P. “Ask the experts: focus on computational chemistry” Future Med Chem. 2011, 3(8):909-21.
52. Tuccinardi T. “Binding-interaction prediction of RNA-binding ligands” Future Med Chem. 2011, 3(6):723-733.
53. Ortore G, Tuccinardi T, Orlandini E, Martinelli A. “Different Binding Modes of Structurally Diverse Ligands for Human D3DAR.” J Chem Inf Model. 2010, 50(12):2162-2175.
54. Bertini S, Calderone V, Carboni I, Maffei R, Martelli A, Martinelli A, Minutolo F, Rajabi M, Testai L, Tuccinardi T, Ghidoni R, Macchia M. “Synthesis of heterocycle-based analogs of resveratrol and their antitumor and vasorelaxing properties.” Bioorg Med Chem. 2010, 18(18):6715-6724.
55. Rizzolio F, La Montagna R, Tuccinardi T, Russo G, Caputi M, Giordano A. “Adenosine Receptor Ligands in Clinical Trials.” Curr Top Med Chem. 2010; 10(10):1036-1045.
56. Chaves S, Marques SM, Matos AM, Nunes A, Gano L, Tuccinardi T, Martinelli A, Santos MA. “New Tris(hydroxypyridinones) as Iron and Aluminium Sequestering Agents: Synthesis, Complexation and In Vivo Studies.” Chemistry – A European Journal 2010, 16(34):10535-10545.
57. Tuccinardi T, Botta M, Giordano A, Martinelli A. “Protein Kinases: Docking and Homology Modeling Reliability.” J Chem Inf Model. 2010, 50(8):1432-1441.
58. Rizzolio F, Tuccinardi T, Caligiuri I, Lucchetti C, Giordano A. “CDK inhibitors: from the bench to clinical trials.” Curr. Drug Targets. 2010;11(3):279-290.
59. Nuti E, Panelli L, Casalini F, Avramova SI, Orlandini E, Santamaria S, Nencetti S, Tuccinardi T, Martinelli A, Cercignani G, D’Amelio N, Maiocchi A, Uggeri F, Rossello A. “Design, Synthesis, Biological Evaluation, and NMR Studies of a New Series of Arylsulfones As Selective and Potent Matrix Metalloproteinase-12 Inhibitors.” J Med Chem 2009, 52(20):6347-6361.
60. Tuccinardi T, Taliani S, Bellandi M, Da Settimo F, Da Pozzo E, Martini C, Martinelli A. “A virtual screening study of the 18-kDa translocator protein using pharmacophore models combined with 3D-QSAR studies.” ChemMedChem 2009, 4(10):1686-1694.
61. Nuti E, Casalini F, Avramova SI, Santamaria S, Cercignani G, Marinelli L, La Pietra V, Novellino E, Orlandini E, Nencetti S, Tuccinardi T, Martinelli A, Lim NH, Visse R, Nagase H, Rossello A. “N-O-Isopropyl Sulfonamido-Based Hydroxamates: Design, Synthesis and Biological Evaluation of Selective Matrix Metalloproteinase-13 Inhibitors as Potential Therapeutic Agents for Osteoarthritis.” J Med Chem 2009, 52(15):4757–4773.
62. Tuccinardi T, Ortore G, Santos MA, Marques SM, Nuti E, Rossello A, Martinelli A. “Multitemplate Alignment Method for the Development of a Reliable 3D-QSAR Model for the Analysis of MMP3 Inhibitors”, J Chem Inf Model. 2009, 49(7):1715-1724.
63. Manera C, Saccomanni G, Adinolfi B, Benetti V, Ligresti A, Cascio M, Tuccinardi T, Lucchesi V, Martinelli A, Nieri P, Masini E, Di Marzo V, Ferrarini PL. “Rational Design, Synthesis and Pharmacological Properties of New 1,8-Naphthyridin-2(1H)-on-3-Carboxamide Derivatives as Highly Selective Cannabinoid-2 Receptor Agonists.” J Med Chem 2009, 52(12):3644-3651.
64. Tuccinardi T. “Docking-Based Virtual Screening: Recent Developments” Comb. Chem. High Throughput Screen. 2009, 12(3):303-314.
65. Brizzi A, Brizzi V, Cascio MG, Corelli F, Guida F, Ligresti A, Maione S, Martinelli A, Pasquini S, Tuccinardi T, Di Marzo V. “New Resorcinol-Anandamide “Hybrids” as Potent Cannabinoid Receptor Ligands Endowed with Antinociceptive Activity in Vivo”, J Med Chem 2009, 52(8):2506-2514.
66. La Motta C, Sartini S, Tuccinardi T, Nerini E, Da Settimo F, Martinelli A. “Computational Studies of Epidermal Growth Factor Receptor: Docking Reliability, Three-Dimensional Quantitative Structure−Activity Relationship Analysis, and Virtual Screening Studies”, J Med Chem 2009, 52(4):964-975.
67. Minutolo F, Bertini S, Granchi C, Marchitiello T, Prota G, Rapposelli S, Tuccinardi T, Martinelli A, Gunther J R, Carlson K E, Katzenellenbogen J A, Macchia M. “Structural Evolutions of Salicylaldoximes as Selective Agonists for Estrogen Receptor Beta”, J Med Chem 2009, 52(3):858-867.
68. Marques SM, Nuti E, Rossello A, Supuran CT, Tuccinardi T, Martinelli A, Santos MA. “Dual Inhibitors of Matrix Metalloproteinases and Carbonic Anhydrases: Iminodiacetyl-Based Hydroxamate−Benzenesulfonamide Conjugates.” J Med Chem 2008, 51(24):7968-7979.
69. Cincinelli R, Cassinelli G, Dallavalle S, Lanzi C, Merlini L, Botta M, Tuccinardi T, Martinelli A, Penco S, Zunino F. “Synthesis, modeling and RET protein kinase inhibitory activity of 3- and 4-substituted-β-carbolin-1-ones.” J Med Chem 2008, 51(24):7777-7787.
70. Baraldi PG, Preti D, Tabrizi MA, Romagnoli R, Saponaro G, Baraldi S, Botta M, Bernardini C, Tafi A, Tuccinardi T, Martinelli A, Varani K, Borea PA. “Structure-Activity Relationship Studies of a New Series of Imidazo[2,1-f]purinones as Potent and Selective A3 Adenosine Receptor Antagonists” Bioorg Med Chem 2008, 16(24):10281-10294.
71. Tuccinardi T, Nuti E, Ortore G, Rossello A, Avramova SI, Martinelli A. “Development of a receptor-based 3D-QSAR study for the analysis of MMP2, MMP3, and MMP9 inhibitors”, Bioorg Med Chem 2008, 16(16):7749-7758.
72. Manera C, Tuccinardi T, Martinelli A. “Indoles and related compounds as cannabinoid ligands” Mini rev. Med. Chem. 2008, 8(4):370-387.
73. Tuccinardi T, Schenone S, Bondavalli F, Brullo C, Bruno O, Ranise A, Zizzari A, Tintori C, Ciampi O, Trincavelli ML, Martini C, Martinelli A, Botta M. “Substituted Pyrazolo[3,4-b]pyridines as potent and selective A1 adenosine antagonists: synthesis, biological evaluation and development of an A1 bovine receptor model”, ChemMedChem 2008, 3(6):898-913.
74. Rapposelli S, Cuboni S, Digiacomo M, Lapucci A, Trincavelli ML, Tuccinardi T, Balsamo A. “Synthesis and AT1 affinity evaluation of benzamidophenyl analogs of known AT1 receptor ligands with similar aromatic skeleton”, Arkivoc 2008, (ii) 268-286.
75. Martinelli A, Tuccinardi T. “Molecular modeling of adenosine receptors: new results and trends” Med. Res. Rev. 2008 28(2):247-277.
76. Cosimelli B, Greco G, Ehlardo M, Novellino E, Da Settimo F, Taliani S, La Motta C, Bellandi M, Tuccinardi T, Martinelli A, Ciampi O, Trincavelli ML, Martini C. “Derivatives of 4-Amino-6-hydroxy-2-mercaptopyrimidine (AHMP) as Novel, Potent, and Selective A3 Adenosine Receptor Antagonists” J Med Chem. 2008, 51(6):1764-1770.
77. Minutolo F, Bellini R, Bertini S, Carboni Isabella, Lapucci A, Pistolesi L, Prota G, Rapposelli S, Solati F, Tuccinardi T, Martinelli A, Stossi F, Carlson K, Katzenellenbogen B, Katzenellenbogen J, Macchia M. “Monoaryl-substituted Salicylaldoximes as Ligands for Estrogen Receptor Beta” J Med Chem. 2008, 51(5):1344-1351.
78. Tuccinardi T, Ortore G, Supuran CT, Rossello A, Martinelli A. “Homology Modelling and Receptor-Based 3D-QSAR study of Carbonic Anhydrase IX”, J Chem Inf Mod. 2007, 47(6):2253-2262.
79. Da Settimo F, Primofiore G, Taliani S, Marini AM, La Motta C, Simorini F, Salerno S, Sergianni V, Tuccinardi T, Martinelli A, Cosimelli B, Greco G, Novellino E, Trincavelli ML, Martini C. “5-Amino-2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one: A Versatile Scaffold to Obtain Potent and Selective A3 Adenosine Receptor Antagonists”, J Med Chem. 2007, 50(23):5676-5684.
80. Tuccinardi T, Martinelli A. “Computational Approaches on Angiotensin Receptors and their Ligands: Recent Developments and Results” Curr. Med. Chem. 2007, 14(29):3105-3121.
81. Manera C, Cascio MG, Benetti V, Allarà M, Tuccinardi T, Martinelli A, Saccomanni G, Vivoli E, Ghelardini C, Di Marzo V, Ferrarini PL. “New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists” Bioorg Med Chem Lett. 2007, 17(23):6505-6510.
82. Brizzi A, Brizzi V, Martinelli A, Tuccinardi T, Cascio MG, Bisogno T, Di Marzo V. “Design, Synthesis and binding studies of new potent ligands of cannabinoid receptor (II)”, Bioorg Med Chem. 2007, 15(16):5406-5416.
83. Tuccinardi T, Manetti F, Schenone S, Martinelli A, Botta M. “Construction and Validation of a RET TK Catalytic Domain by Homology Modeling”, J Chem Inf Mod. 2007 47(2):644-655.
84. Nuti E, Tuccinardi T, Rossello A. “Matrix Metalloproteinase Inhibitors: New Challenges in the Era of Post Broad-Spectrum Inhibitors” Curr. Pharm. Design. 2007, 13(20):2087-2100.
85. Tuccinardi T, Nuti E, Ortore G, Supuran CT, Rossello A, Martinelli A. “Analysis of human Carbonic Anhydrase II: Docking Reliability and Receptor-Based 3D-QSAR study”, J Chem Inf Mod. 2007 47(2):515-525.
86. Tuccinardi T, Cascio MG, Di Marzo V, Manera C, Ortore G, Saccomanni G, Martinelli A. “Structure-Based Virtual screening: Identification of novel CB2 receptor ligands”, LDDD. 2007, 4(1):15-19.
87. Santos AM, Marques SM, Tuccinardi T, Carelli P, Panelli L, Rossello A. “Design, Synthesis And Molecular Modeling Study Of Iminodiacetyl Monohydroxamic Acid Derivatives As Mmp Inhibitors”, Bioorg Med Chem. 2006, 14(22):7539-7550.
88. Manera C, Benetti V, Castelli MP, Cavallini T, Lazzarotti S, Pibiri F, Saccomanni G, Tuccinardi T, Vannacci A, Martinelli A, Ferrarini PL. “Design, synthesis and biological evaluation of new 1,8-naphthyridin-4(1H)-on-3-carboxamide and quinolin-4(1H)-on-3-carboxamide derivatives as CB2 selective agonists”, J Med Chem. 2006, 49(16):5947-5957.
89. Tuccinardi T, Bertini S, Martinelli A, Minutolo F, Ortore G, Placanica G, Prota G, Rapposelli S, Carlson KE, Katzenellenbogen JA, Macchia M. “Synthesis of Anthranylaldoxime Derivatives as Estrogen Receptor Ligands and Computational Prediction of Binding Modes”, J Med Chem. 2006, 49(16):5001-5012.
90. Tafi A, Bernardini C, Botta M, Corelli F, Andreini M, Martinelli A, Ortore G, Baraldi PG, Fruttarolo F, Borea PA, Tuccinardi T. “Pharmacophore based receptor modeling: a novel approach to protein model optimization. The case of Adenosine A3 receptor antagonists”, J Med Chem. 2006, 49(14):4085-4097.
91. Martinelli A, Tuccinardi T. “GPCR modeling: methods and validation. An overview of recent developments” Exp. Opin. on Drug Disc. 2006, 1(5):459-476.
92. Tuccinardi T, Calderone V, Rapposelli S, Martinelli A. “Proposal of a new binding orientation for non-peptide AT1 antagonists: homology model, docking and 3D-QSAR analysis”, J Med Chem. 2006, 49(14):4305-4316.
93. Minutolo F, Bertini S, Martinelli A, Ortore G, Placanica G, Prota G, Rapposelli S, Tuccinardi T, Sheng S, Carlson KE, Katzenellenbogen BS, Katzenellenbogen JA, Macchia M. “Salicylaldoximes and anthranylaldoximes as alternatives phenol-based estrogen receptor ligands”, Arkivoc 2006, (viii) 83-94.
94. Tuccinardi T, Martinelli A, Nuti E, Carelli P, Balzano F, Uccello-Barretta G, Murphy G, Rossello A. “Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamides”, Bioorg Med Chem. 2006, 14(12):4260-4276 (cover of the Volume).
95. Tuccinardi T, Manera C, Ortore G, Saccomanni G, Martinelli A. “Adenosine receptor modelling. A1/A2a selectivity”, Eur J Med Chem. 2006, 41(3):321-329.
96. Ortore G, Tuccinardi T, Bertini S, Martinelli A. “A theoretical study to investigate D2DAR/D4DAR selectivity: receptor modeling and molecular docking of dopaminergic ligands”, J Med Chem. 2006, 49(4):1397-1407.
97. Tuccinardi T, Ferrarini PL, Manera C, Ortore G, Saccomanni G, Martinelli A. “Cannabinoid CB2/CB1 selectivity. Receptor modelling and automated docking analysis”, J Med Chem. 2006, 49(3):984-994.
98. Minutolo F, Bertini S, Betti L, Danesi R, Gervasi G, Giannaccini G, Martinelli A, Papini A, Peroni E, Placanica G, Rapposelli S, Tuccinardi T, Macchia M. “Synthesis of stable analogues of geranylgeranyl diphosphate possessing a (z,e,e)-geranylgeranyl side-chain, docking analysis and biological assays for their prenyl protein transferase inhibitory activity”, Chem Med Chem. 2006, 1(2):218-224.
99. Manera C, Betti L, Cavallini T, Giannaccini G, Martinelli A, Ortore G, Saccomanni G, Trincavelli L, Tuccinardi T, Ferrarini PL. “1,8-Naphthyridin-4-one derivatives as new ligands of A2A adenosine receptors”, Bioorg Med Chem Lett. 2005, 15(20):4604-4610.
100. Rossello A, Nuti E, Catalani MP, Carelli P, Orlandini E, Rapposelli S, Tuccinardi T, Atkinson SJ, Murphy G, Balsamo A. “A new development of matrix metalloproteinase inhibitors: twin hydroxamic acids as potent inhibitors of MMPs”, Bioorg Med Chem Lett. 2005, 15(9):2311-2314.
101. Ferrarini PL, Betti L, Cavallini T, Giannaccini G, Lucacchini A, Manera C, Martinelli A, Ortore G, Saccomanni G, Tuccinardi T. “Study on affinity profile toward native human and bovine adenosine receptors of a series of 1,8-naphthyridine derivatives”, J Med Chem. 2004, 47(12):3019-3031.