Research activity:

The main interest is about the development of new regio- and stereoselective synthetic methodologies dealing with:

1) Reactivity of strained heterocyclic systems
2) Development of new catalytic synthetic processes
3) Asymmetric catalysis using organometallic reagents

FOR TOPICS 1-3, please see list of publications

4) Synthesis of novel heterocyclic scaffolds of biological/pharmaceutical interest

INTERNATIONAL PATENTS:

2025. 1,3-DIAZA-4-OXA-[3.3.1]-BICYCLIC DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINE, PARTICULARLY FOR THE TREATMENT OF OBESITY, DIABETES, AND/OR NEURODEGENERATIVE DISEASES. Assignee: University of Pisa, Italy. WO 2025/032536 A1.

2024 Stereoselective synthesis of intermediates and synthesis of quinagolides Assignee: Ferring B.V. World Intellectual Property Organization, WO2024153752 A1 2024-07-25

2021 – Granted EP Patent DIAZO-4-OXA-[3.3.1]-BICYCLIC DERIVATIVES, PROCESS FOR THEIR MANUFACTURE AND THEIR USE AS A MEDICAMENT, IN PARTICULAR FOR TREATING DIABETES -Assignee: University of Pisa, Italy. EP 3 630 780 B1.

2020 – Granted US Patent DIAZO-4-OXA-[3.3.1]-BICYCLIC DERIVATIVES, PROCESS FOR THEIR MANUFACTURE AND THEIR USE AS A MEDICAMENT, IN PARTICULAR FOR TREATING DIABETES  US 2020/0172552 A1 and US 10,913,751 B2.

2018 –1,3-DIAZO-4-OXA-[3.3.1]-BICYCLIC DERIVATIVES, PROCESS FOR THEIR MANUFACTURE AND THEIR USE AS A MEDICAMENT, IN PARTICULAR FOR TREATING DIABETES-Assignee: University of Pisa, Italy. WO2018/220542-–  Brevetto http://hdl.handle.net/11568/938637