ZEBRAFISH AVATAR: TOWARDS PERSONALISED MEDICINE<\/p>\n
Cancer continues to pose a major therapeutic challenge, as for some common solid cancers, the prospects of cure remains remote, whilst their incidence remains high. In this project, we will validate the use of zebrafish embryos for cost\/ethical sustainable co-clinical trial. This should allow to identify the best personalised therapeutic regimen as well as to reduce costs and toxicity associated to non personalised approaches. Such a bench-to-bedside transition will facilitate a long term robust strategy that is economically feasible and clinically effective to manage cancer.<\/p>\n
MAIN COLLABORATIONS<\/p>\n
Prof Luca Morelli, UNIPI<\/p>\n
Dr Enrico Vasile, AOUP<\/p>\n
Dr Luca Pollina, AOUP<\/p>\n
Dr Francesco Tantussi, IIT<\/p>\n
PUBLICATIONS<\/p>\n\n\n
Di Franco, G., Usai, A., Piccardi, M., Cateni, P., Palmeri, M., Pollina, L.E., Gaeta, R., Marmorino, F., Cremolini, C., Dente, L., Massolo, A., Raffa, V.<\/strong>, Morelli, L. Zebrafish Patient-Derived Xenograft Model to Predict Treatment Outcomes of Colorectal Cancer Patients (2022) Biomedicines, 10 (7), art. no. 1474, DOI: 10.3390\/biomedicines10071474<\/p>\n\n\n\n Usai, A., Di Franco, G., Piccardi, M., Cateni, P., Pollina, L.E., Vivaldi, C., Vasile, E., Funel, N., Palmeri, M., Dente, L., Falcone, A., Giunchi, D., Massolo, A., Morelli, L., Raffa, V.<\/strong> Zebrafish patient-derived xenografts identify chemo-response in pancreatic ductal adenocarcinoma patients (2021) Cancers, 13 (16), art. no. 4131, DOI: 10.3390\/cancers13164131<\/p>\n\n\n\n Usai, A., Di Franco, G., Colucci, P., Pollina, L.E., Vasile, E., Funel, N., Palmeri, M., Dente, L., Falcone, A., Morelli, L., Raffa, V. A model of a zebrafish avatar for co-clinical trials (2020) Cancers, 12 (3), art. no. 677, DOI: 10.3390\/cancers12030677<\/p>\n\n\n\n Di Franco, G., Usai, A., Funel, N., Palmeri, M., Rosamaria Montesanti, I.E., Bianchini, M., Gianardi, D., Furbetta, N., Guadagni, S., Vasile, E., Falcone, A., Pollina, L.E., Raffa, V., Morelli, L. Use of zebrafish embryos as avatar of patients with pancreatic cancer: A new xenotransplantation model towards personalized medicine. (2020) World Journal of Gastroenterology, 26 (21), pp. 2792-2809. DOI: 10.3748\/wjg.v26.i21.2792<\/p>\n","protected":false},"excerpt":{"rendered":" ZEBRAFISH AVATAR: TOWARDS PERSONALISED MEDICINE Cancer continues to pose a major therapeutic challenge, as for some common solid cancers, the…<\/p>\n