{"id":529,"date":"2026-03-04T14:08:30","date_gmt":"2026-03-04T13:08:30","guid":{"rendered":"https:\/\/people.unipi.it\/vittoria_raffa\/?page_id=529"},"modified":"2026-03-04T14:08:31","modified_gmt":"2026-03-04T13:08:31","slug":"guidance-of-axonal-pathfinding-via-nano-switches-gap","status":"publish","type":"page","link":"https:\/\/people.unipi.it\/vittoria_raffa\/projects\/guidance-of-axonal-pathfinding-via-nano-switches-gap\/","title":{"rendered":"Guidance of Axonal Pathfinding via nano-switches (GAP)"},"content":{"rendered":"\n
\"\"<\/a><\/figure>\n\n\n\n
\"\"<\/a><\/figure>\n\n\n\n

GAP project addresses one of the most complex challenges in neuroscience: providing the instructions that enable damaged nervous tissue to rebuild its connections. Neurons must extend their projections\u2014axons\u2014in order to establish the correct connections. Axon navigation is a crucial step in repair: building a functional nervous system means instructing some axons where to regenerate and others where not to go. If these instructions are incorrect, functional neural circuits cannot form.<\/p>\n\n\n\n

Current technologies do not allow effective guidance of axonal growth within nervous tissue. GAP therefore proposes an innovative solution: engineering neurons with \u201cmacromolecular switches\u201d to create a \u201cmolecular map\u201d that directs them along the correct path, paving the way for new therapeutic strategies to address spinal cord injuries, brain lesions, and neurodegenerative diseases.<\/p>\n","protected":false},"excerpt":{"rendered":"

GAP project addresses one of the most complex challenges in neuroscience: providing the instructions that enable damaged nervous tissue to…<\/p>\n

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