{"id":205,"date":"2019-02-03T13:10:27","date_gmt":"2019-02-03T12:10:27","guid":{"rendered":"http:\/\/people.unipi.it\/ugo_borello\/?page_id=205"},"modified":"2025-06-27T16:42:33","modified_gmt":"2025-06-27T14:42:33","slug":"comparative-neurobiology","status":"publish","type":"page","link":"https:\/\/people.unipi.it\/ugo_borello\/teaching\/comparative-neurobiology\/","title":{"rendered":"Comparative Neurobiology"},"content":{"rendered":"<p><strong>Comparative Neurobiology (BIO\/06)<\/strong><\/p>\n<p><strong>CFU: 3<\/strong><\/p>\n<p><strong>Learning outcomes:<\/strong><\/p>\n<p>Analysis of the structural and functional principles of brain development and evolution<\/p>\n<p><strong>Syllabus <\/strong><\/p>\n<p>Development and structure of the vertebrate brain. Vertebrate telencephalon evolution. Embryonic and adult corticogenesis. The principles of brain evolution as a paradigm for the study of molecular etiology of neuro-psychiatric pathologies<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Course description:<\/strong><\/p>\n<p><strong>History of comparative neurobiology<\/strong><\/p>\n<p>Study of vertebrate neurobiology from Aristotle to the present day: experimental approaches and schools of thought.<\/p>\n<p><strong>Development and structure of the vertebrate brain<\/strong><\/p>\n<p>Analysis of the molecular and cellular mechanisms of the central nervous system development. Proliferation and differentiation of neuronal precursor cells: parameters that modify the size and composition of the brain.<\/p>\n<p>Signaling centers in the developing neural tube. Regionalization and ontogenesis of adult brain structures.<\/p>\n<p>The brain bauplan in vertebrates: the neuromeric model. Overview of neuroanatomy.<\/p>\n<p>Regulation of gene expression during brain development. Genes and genomic regions specific to Homo sapiens and brain development.<\/p>\n<p>Molecular etiology of microcephaly as a paradigm of human cortex development.<\/p>\n<p><strong>Evolutionary changes in the size and structur of the brain.<\/strong><\/p>\n<p>Methods of study of comparative neurobiology: molecular anatomy of the brain.<\/p>\n<p>Online resources for the study of comparative neurobiology.<\/p>\n<p>The dimensions of the vertebrate brain: absolute and relative dimensions.<\/p>\n<p>Cellular composition of the mammalian brain: how many and which cells compose the vertebrate brain?<\/p>\n<p>Correlation between brain size and neuronal connections.<\/p>\n<p>Functional significance of the change in brain size and structure. Absolute and relative size of the individual brain regions<\/p>\n<p>Definition and evolution of intelligence.<\/p>\n<p>The brain as a complex system.<\/p>\n<p><strong>Evolution of the neocortex in mammals: what makes us human<\/strong><\/p>\n<p>Differences and homologies of the human brain compared to other species.<\/p>\n<p>Ontogeny and cytoarchitecture of the neocortex. Lamination and girification of the cortex.<\/p>\n<p>A special case: the prefrontal cortex in mammals.<\/p>\n<p><strong>Neuronal regeneration and adult neurogenesis under an evolutionary perspective<\/strong><\/p>\n<p>Regeneration mechanisms and adult neurogenesis in different species. The evolutionary significance of neuronal regeneration; applications to biomedicine.<\/p>\n<p>Comparative neurobiology as an essential science in the use and choice of experimental systems for the study of neurobiology and neuro-psychiatric pathologies.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Couse attendance:<\/strong><\/p>\n<p>Non obbligatoria ma fortemente consigliata<\/p>\n<p>Not mandatory but strongly adviced<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Assessments:<\/strong><\/p>\n<p><em>In itinere\u00a0<\/em>verification with a group discussion of specific articles provided during the course.<\/p>\n<p>Oral exam at the end of the course<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Official language:<\/strong><\/p>\n<p>English<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Course prerequisites:<\/strong><\/p>\n<p>Comparative anatomy<\/p>\n<p>Cellular and molecular biology<\/p>\n<p>Developmental biology<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Suggested books<\/strong><\/p>\n<p>Principles of Brain Evolution, G.F. Striedter, Sinauer 2005<\/p>\n<p>Building Brains, Price et al., Wiley 2017<\/p>\n<p>&nbsp;<\/p>\n<p>Original papers indicated during the course<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Teacher info:<\/strong><\/p>\n<p>Nome: Ugo Borello<\/p>\n<p>Dipartimento di Biologia<\/p>\n<p>Telefono:050-2211492<\/p>\n<p>E-mail: ugo.borello@unipi.it<\/p>\n<p>Pagina web: https:\/\/people.unipi.it\/ugo_borello\/<\/p>\n<p>Orario di ricevimento: previo appuntamento.<\/p>\n<p>Luogo di ricevimento: Unit\u00e0 di Biologia Cellulare e dello Sviluppo, S.S. 12 Abetone e Brennero, 4, Pisa. I-56127<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Comparative Neurobiology (BIO\/06) CFU: 3 Learning outcomes: Analysis of the structural and functional principles of brain development and evolution Syllabus Development and structure of the vertebrate brain. Vertebrate telencephalon evolution. Embryonic and adult corticogenesis. The principles of brain evolution as a paradigm for the study of molecular etiology of neuro-psychiatric pathologies &nbsp; Course description: History [&hellip;]<\/p>\n","protected":false},"author":527,"featured_media":0,"parent":166,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-205","page","type-page","status-publish","hentry"],"acf":[],"featured_image_src":null,"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.0 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Comparative Neurobiology - UGO BORELLO<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/people.unipi.it\/ugo_borello\/teaching\/comparative-neurobiology\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Comparative Neurobiology - UGO BORELLO\" \/>\n<meta property=\"og:description\" content=\"Comparative Neurobiology (BIO\/06) CFU: 3 Learning outcomes: Analysis of the structural and functional principles of brain development and evolution Syllabus Development and structure of the vertebrate brain. Vertebrate telencephalon evolution. Embryonic and adult corticogenesis. 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