{"id":8,"date":"2015-04-08T11:14:00","date_gmt":"2015-04-08T09:14:00","guid":{"rendered":"http:\/\/people.unipi.it\/cloner\/?page_id=8"},"modified":"2016-07-14T10:15:43","modified_gmt":"2016-07-14T08:15:43","slug":"publications","status":"publish","type":"page","link":"https:\/\/people.unipi.it\/tiziano_tuccinardi\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"
    \n
  1. Poli G, Martinelli Tuccinardi T. A, \u201cReliability analysis and optimization of the consensus docking approach for the development of virtual screening studies\u201d J Enzyme Inhib Med Chem. 2016 ASAP.<\/li>\n
  2. Petrou A, Geronikaki A, Terzi E, Ozensoy Guler O, Tuccinardi T, Supuran CT. \u201cInhibition of carbonic anhydrase isoforms I, II, IX and XII with secondary sulfonamides incorporating benzothiazole scaffolds\u201d J Enzyme Inhib Med Chem. 2016 ASAP.<\/li>\n
  3. Poli G, Gelain A, Porta F, Asai A, Martinelli A, Tuccinardi T. \u201cIdentification of a new STAT3 dimerization inhibitor through a pharmacophore-based virtual screening approach\u201d J Enzyme Inhib Med Chem. 2016 ASAP.<\/li>\n
  4. Tuccinardi T, Poli G, Corchia I, Granchi C, Lapillo M, Macchia M, Minutolo F, Ortore G, Martinelli A. \u201cA Virtual Screening Study for Lactate Dehydrogenase 5 Inhibitors by using a Pharmacophore-Based Approach\u201d Mol. Inf. 2016 ASAP.<\/li>\n
  5. Granchi C, Lapillo M, Russo Spena C, Rizzolio F, Tuccinardi T, Martin TA, Carlson KE, Katzenellenbogen JA, Minutolo F. \u201cCyclic-ketoximes as ER beta-selective agonists\u201d ChemMedChem 2016 ASAP.<\/li>\n
  6. Kumar S, Ceruso M, Tuccinardi T, Supuran CT, Sharma PK. \u201cPyrazolylbenzo[d]imidazoles as new potent and selective inhibitors of carbonic anhydrase isoforms hCA IX and XII\u201d Bioorg Med Chem 201624(13):2907-29013.<\/li>\n
  7. Tabrizi MA, Baraldi PG, Ruggiero E, Saponaro G, Baraldi S, Poli G, Tuccinardi T, Ravani A, Vincenzi F, Borea PA, Varani K. \u201cSynthesis and Structure Activity Relationship Investigation of Triazolo[1,5-a]pyrimidines as CB2 Cannabinoid Receptor Inverse Agonists\u201d Eur J Med Chem. 2016 113:11-27.<\/li>\n
  8. Camodeca C, Nuti E, Tepshi L, Boero S, Tuccinardi T, Stura EA, Poggi A, Zocchi MR, Rossello A. \u201cDiscovery of a new selective inhibitor of A Disintegrin And Metalloprotease 10 (ADAM-10) able to reduce the shedding of NKG2D ligands in Hodgkin’s lymphoma cell models\u201d Eur J Med Chem. 2016 111:193-201.<\/li>\n
  9. Granchi C, Rizzolio F, Bordoni V, Caligiuri I, Manera C, Macchia M, Minutolo F, Martinelli A, Giordano A, Tuccinardi T. \u201c4-Aryliden-2-methyloxazol-5(4H)-one as a new scaffold for selective reversible MAGL inhibitors\u201d J Enzyme Inhib Med Chem. 2016 31(1):137-146.<\/li>\n
  10. Granchi C, Qian Y, Yeon Lee H, Paterni I, Pasero C, Iegre J, Carlson KE, Tuccinardi T, Chen X, Katzenellenbogen JA, Hergenrother PJ, Minutolo FM. \u201cSalicylketoximes That Target Glucose Transporter 1 Restrict Energy Supply to Lung Cancer Cells\u201d ChemMedChem. 2015 10(11):1892-1900.<\/li>\n
  11. Nuti E, Cantelmo AR, Gallo C, Bruno A, Bassani B, Camodeca C, Tuccinardi T, Vera L, Orlandini E, Nencetti S, Stura EA, Martinelli A, Dive V, Albini A, Rossello A. \u201cN-O-Isopropyl Sulfonamido-Based Hydroxamates as Matrix Metalloproteinase Inhibitors: Hit Selection and in vivo Antiangiogenic Activity\u201d J Med Chem. 2015 58(18):7224-7240.<\/li>\n
  12. Tuccinardi T, Poli G, dell\u2019Agnello M, Granchi C, Minutolo F, Martinelli A. \u201cReceptor-based virtual screening evaluation for the identification of estrogen receptor \u03b2 ligands\u201d J Enzyme Inhib Med Chem. 2015 30(4):662-670.<\/li>\n
  13. Krasavin M, Korsakov M, Dorogov M, Tuccinardi T, Dedeoglu N, Supuran CT. \u201cProbing the \u2018bipolar\u2019 nature of the carbonic anhydrase active site: aromatic sulfonamides containing 1,3-oxazol-5-yl moiety as picomolar inhibitors of cytosolic CA I and CA II isoforms\u201d Eur J Med Chem. 2015 101:334-347.<\/li>\n
  14. Nassini R, Fusi C, Materazzi S, Coppi E, Tuccinardi T, Marone IM, De Logu F, Preti D, Tonello R, Chiarugi A, Patacchini R, Geppetti P, Benemei S. \u201cThe TRPA1 channel mediates the analgesic action of dipyrone and pyrazolone derivatives\u201d Br J Pharmacol. 2015 172(13):3397-3411.<\/li>\n
  15. Tintori C, La Sala G, Vignaroli G, Botta L, Fallacara AL, Falchi F, Radi M, Zamperini C, Dreassi E, Dello Iacono L, Orioli D, Biamonti G, Garbelli M, Lossani A, Gasparrini F, Tuccinardi T, Laurenzana I, Angelucci A, Maga G, Schenone S, Brullo C, Musumeci F, Desogus A, Crespan E, Botta M. \u201cStudies on the ATP binding site of Fyn kinase for the identification of new inhibitors and their evaluation as potential agents against tauopathies and tumors.\u201d J Med Chem. 2015 58(11):4590-4609.<\/li>\n
  16. Bader A, Tuccinardi T, Granchi C, Martinelli A, Macchia M, Minutolo F, De Tommasi N, Braca A. \u201cPhenylpropanoids and Flavonoids from Phlomis kurdica as Inhibitors of Human Lactate Dehydrogenase\u201d Phytochem. 2015 116:262-268.<\/li>\n
  17. Tabrizi MA, Baraldi PG, Ruggiero E, Saponaro G, Baraldi S, Romagnoli R, Martinelli A, Tuccinardi T. \u201cPyrazole phenylcyclohexylcarbamates as inhibitors of human fatty acid amide hydrolases (FAAH)\u201d Eur J Med Chem. 2015 97:289-305.<\/li>\n
  18. Granchi C, Capecchi A, Del Frate G, Martinelli A, Macchia M, Minutolo F, Tuccinardi T. \u201cDevelopment and Validation of a Docking-Based Virtual Screening Platform for the Identification of New Lactate Dehydrogenase Inhibitors\u201d Molecules. 2015, 20(5):8772-8790.<\/li>\n
  19. Poli G, Giuntini N, Martinelli A, Tuccinardi T. \u201cApplication of a FLAP-Consensus Docking Mixed Strategy for the Identification of New FAAH Inhibitors\u201d J Chem Inf Model. 2015 55(3):667-675.<\/li>\n
  20. Di BussoloV, Calvaresi EC, Granchi C, Del Bino L, Frau I, Dasso Lang MC, Tuccinardi T, Macchia M, Martinelli A, Hergenrother PJ, Minutolo F. \u201cSynthesis and biological evaluation of non-glucose glycoconjugated N-hydroyxindole class LDH inhibitors as anticancer agents\u201d. RSC Adv. 2015, 5(26): 19944-19954.<\/li>\n
  21. Paterni I, Bertini S, Granchi C, Tuccinardi T, Macchia M, Martinelli A, Caligiuri I, Toffoli G, Rizzolio F, Carlson KE, Katzenellenbogen BS, Katzenellenbogen JA, Minutolo F. \u201cHighly selective salicylketoxime-based estrogen receptor beta agonists display antiproliferative activities in a glioma model.\u201d J Med Chem. 2015, 58(3):1184\u20131194.<\/li>\n
  22. Enyedy EA, D\u00f6m\u00f6t\u00f6r O, Bali K, Het\u00e9nyi A, Tuccinardi T, Keppler BK. \u201cInteraction of the anticancer gallium(III) complexes of 8-hydroxyquinoline and maltol with human serum proteins.\u201d J Biol Inorg Chem. 2015, 20(1):77-88.<\/li>\n
  23. Fusi C, Materazzi S, Benemei S, Coppi E, Trevisan G, Marone I, Minocci D, De Logu F, Tuccinardi T, Di Tommaso M, Susini T, Moneti G, Pieraccini G, Geppetti P, Nassini R. \u201cSteroidal and non-steroidal third-generation aromatase inhibitors induce pain-like symptoms via TRPA1.” Nature Communications 2014, 5:5736.<\/li>\n
  24. Tuccinardi T, Poli G, Romboli V, Giordano A, Martinelli A. \u201cExtensive consensus docking evaluation for ligand pose prediction and virtual screening studies” J Chem Inf Model. 2014, 54(10):2980-2986.<\/li>\n
  25. Poli G, Martinelli A, Tuccinardi T. \u201cComputational Approaches for the Identification and Optimization of Src Family Kinases Inhibitors.\u201d Curr Med Chem. 2014, 21(28):3281-3293.<\/li>\n
  26. Tuccinardi T, Granchi C, Rizzolio F, Caligiuri I, Battistello V, Toffoli G, Minutolo F, Macchia M, Martinelli A. \u201cIdentification and characterization of a new reversible MAGL inhibitor\u201d Bioorg Med Chem. 2014, 22(13):3285-3291.<\/li>\n
  27. Wong CH, Nguyen L, Peh J, Luu LM, Sanchez JS, Richardson SL, Tuccinardi T, Tsoi H, Chan WY, Chan HY, Baranger AM, Hergenrother PJ, Zimmerman SC. \u201cTargeting Toxic RNAs that Cause Myotonic Dystrophy Type 1 (DM1) with a Bisamidinium Inhibitor.\u201d J Am Chem Soc. 2014, 136(17):6355-6361.<\/li>\n
  28. Digilio G, Tuccinardi T, Casalini F, Cassino C, Dias DM, Geraldes CFGC, Catanzaro V, Maiocchi A, Rossello A. \u201cStudy of the binding interaction between fluorinated Matrix Metalloproteinase inhibitors and Human Serum Albumin.\u201d Eur J Med Chem. 2014, 79:13-23.<\/li>\n
  29. D\u00f6m\u00f6t\u00f6r O, Tuccinardi T, Karcz D, Walsh M, Creaven BS, Enyedy E. \u201cInteraction of anticancer reduced Schiff base coumarin derivatives with human serum albumin investigated by fluorescence quenching and molecular modeling\u201d Bioorg Chem. 2014, 52:16-23.<\/li>\n
  30. Malfitano AM, Laezza C, Saccomanni G, Tuccinardi T, Manera C, Martinelli A, Ciaglia E, Pisanti S, Vitale M, Gazzerro P, Bifulco M. \u201cImmune-Modulation and Properties of Absorption and Blood Brain Barrier Permeability of 1,8-Naphthyridine Derivatives.\u201d J Neuroimmune Pharmacol. 2013, 8(5):1077-1086.<\/li>\n
  31. Tuccinardi T, Granchi C, Iegre J, Paterni I, Bertini S, Macchia M, Martinelli A, Qian Y, Chen X, Minutolo F. \u201cOxime-based inhibitors of glucose transporter 1 displaying antiproliferative effects in cancer cells.\u201d Bioorg Med Chem. Lett. 2013, 23(24):6923-6927.<\/li>\n
  32. Calvaresi EC, Granchi C, Tuccinardi T, Di Bussolo V, Huigens III RW, Lee HY, Palchaudhuri R, Macchia M, Martinelli A, Minutolo F, Hergenrother PJ. \u201cDual Targeting of the Warburg Effect with a Glucose-Conjugated Lactate Dehydrogenase Inhibitor\u201d Chembiochem. 2013, 14(17):2263-2267.<\/li>\n
  33. Poli G, Tuccinardi T, Rizzolio F, Caligiuri I, Botta L, Granchi C, Ortore G, Minutolo F, Schenone S, Martinelli A. \u201cIdentification of new FYN kinase inhibitors using a FLAP-based approach.\u201d J Chem Inf Model. 2013, 53(10):2538-2547.<\/li>\n
  34. Granchi C, Calvaresi EC, Tuccinardi T, Paterni I, Macchia M, Martinelli A, Hergenrother PJ, Minutolo F. \u201cAssessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2- carboxylate (NHI) and malonic (Mal) scaffolds.\u201d Org Biomol Chem. 2013, 11(38):6588-6596.<\/li>\n
  35. Aghazadeh Tabrizi M, Baraldi PG, Saponaro G, Moorman A, Romagnoli R, Preti D, Baraldi S, Ruggiero E, Tintori C, Tuccinardi T, Vincenzi F, Borea PA, Varani K. \u201cDiscovery of 7-Oxo-pyrazolo[1,5-a]pyrimidine-6-carboxamides as Potent and Selective CB2 Cannabinoid Receptor Inverse Agonists.\u201d J Med Chem. 2013, 56(11):4482-4496.<\/li>\n
  36. Malfitano AM, Laezza C, D’Alessandro A, Procaccini C, Saccomanni G, Tuccinardi T, Manera C, Macchia M, Matarese G, Gazzerro P, Bifulco M. \u201cEffects on Immune Cells of a New 1,8-Naphthyridin-2-One Derivative and Its Analogues as Selective CB2 Agonists: Implications in Multiple Sclerosis\u201d PLoS One. 2013 May 1;8(5):e62511.<\/li>\n
  37. Tuccinardi T, Bertini S, Granchi C, Ortore G, Macchia M, Minutolo F, Martinelli A, Supuran CT. \u201cSalicylaldoxime derivatives as new leads for the development of Carbonic Anhydrase inhibitors\u201d Bioorg Med Chem. 2013, 21(6):1511-1515.<\/li>\n
  38. Wong CH, Richardson SL, Ho YJ, Lucas AM, Tuccinardi T, Baranger AM, Zimmerman SC. \u201cInvestigating the Binding Mode of an Inhibitor of the MBNL1\u22c5RNA Complex in Myotonic Dystrophy Type 1 (DM1) Leads to the Unexpected Discovery of a DNA-Selective Binder.\u201d Chembiochem. 2012, 13(17):2505-2509.<\/li>\n
  39. Manera C, Saccomanni G, Malfitano AM, Bertini S, Castelli F, Laezza C, Ligresti A, Lucchesi V, Tuccinardi T, Rizzolio F, Bifulco M, Di Marzo V, Giordano A, Macchia M, Martinelli A. \u201cRational design, synthesis and anti-proliferative properties of new CB2 selective cannabinoid receptor ligands: An investigation of the 1,8-naphthyridin-2(1H)-one scaffold.\u201d Eur J Med Chem. 2012, 52:284-294.<\/li>\n
  40. Ortore G, Tuccinardi T, Martinelli A. \u201cComputational Studies on Translocator Protein (tspo) and its Ligands.\u201d Curr Top Med Chem. 2012, 12(4):352-359.<\/li>\n
  41. Marques SM, Tuccinardi T, Nuti E, Santamaria S, Andr\u00e9 V, Rossello A, Martinelli A, Santos MA. \u201cNovel 1-hydroxypiperazine-2,6-diones as new leads in the inhibition of metalloproteinases.\u201d J Med Chem. 2011, 54(24):8289\u20138298.<\/li>\n
  42. Granchi C, Roy S, Mottinelli M, Nardini E, Campinoti F, Tuccinardi T, Lanza M, Betti L, Giannaccini G, Lucacchini A, Martinelli A, Macchia M, Minutolo F. Synthesis of sulfonamide-containing N-hydroxyindole-2-carboxylates as inhibitors of human lactate dehydrogenase-isoform 5. Bioorg Med Chem Lett. 2011, 21(24):7331-7336.<\/li>\n
  43. Granchi C, Roy S, De Simone A, Salvetti I, Tuccinardi T, Martinelli A, Macchia M, Lanza M, Betti L, Giannaccini G, Lucacchini A, Giovannetti E, Sciarrillo R, Peters GJ, Minutolo F. \u201cN-Hydroxyindole-based inhibitors of lactate dehydrogenase against cancer cell proliferation.\u201d Eur J Med Chem. 2011, 46(11):5398-5407.<\/li>\n
  44. Granchi C, Roy S, Del Fiandra C, Tuccinardi T, Lanza M, Betti L, Giannaccini G, Lucacchini A, Martinelli A, Macchia M, Minutolo F. \u201cTriazole-substituted N-hydroxyindol-2-carboxylates as inhibitors of isoform 5 of human lactate dehydrogenase (hLDH5)\u201d MedChemComm. 2011, 2(7), 638-643.<\/li>\n
  45. Enyedy EA, Horv\u00e1th L, Het\u00e9nyi A, Tuccinardi T, Hartinger CG, Keppler BK, Kiss T. \u201cInteractions of the carrier ligands of antidiabetic metal complexes with human serum albumin: a combined spectroscopic and separation approach with molecular modeling studies\u201d Bioorg Med Chem. 2011, 19(14):4202-4210.<\/li>\n
  46. Tuccinardi T, Martinelli A. Protein Kinase Homology Models: Recent Developments and Results. Curr Med Chem. 2011;18(19):2848-2853.<\/li>\n
  47. Carrasco MP, Enyedy EA, Krupenko NI, Krupenko SA, Nuti E, Tuccinardi T, Santamaria S, Rossello A, Martinelli A, Santos MA. \u201cNovel Folate-Hydroxamate Based Antimetabolites: Synthesis and Biological Evaluation.\u201d Med Chem. 2011, 7(4):265-274.<\/li>\n
  48. Tuccinardi T, Zizzari AT, Brullo C, Daniele S, Musumeci F, Schenone S, Trincavelli ML, Martini C, Martinelli A, Giorgi G, Botta M. \u201cSubstituted pyrazolo[3,4-b]pyridines as human A(1) adenosine antagonists: Developments in understanding the receptor stereoselectivity.\u201d Org Biomol Chem. 2011, 9(12):4448-4455 (cover of the Volume).<\/li>\n
  49. Bertini S, De Cupertinis A, Granchi C, Bargagli B, Tuccinardi T, Martinelli A, Macchia M, Gunther JR, Carlson KE, Katzenellenbogen JA, Minutolo F. \u201cSelective And Potent Agonists For Estrogen Receptor Beta Derived From Molecular Refinements Of Salicylaldoximes\u201d Eur Med Chem. 2011, 46(6):2453-2462.<\/li>\n
  50. Granchi C, Roy S, Giacomelli C, Macchia M, Tuccinardi T, Martinelli A, Lanza M, Betti L, Giannaccini G, Lucacchini A, Funel N, Leo\u0301n LG, Giovannetti E, Peters GJ, Palchaudhuri R, Calvaresi EC, Hergenrother PJ, Minutolo F. \u201cDiscovery of N-Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform A (LDH-A) as Starvation Agents against Cancer Cells.\u201d J Med Chem. 2011, 54(6):1599-1612.<\/li>\n
  51. Bajorath J, Barreca ML, Bender A, Bryce R, Hutter M, Laggner C, Laughton C, Martin Y, Mitchell J, Padova A, Renner S, Selzer PM, Sherman W, Sippl W, Taft C, Tuccinardi T, Vistoli G, Willett P. \u201cAsk the experts: focus on computational chemistry\u201d Future Med Chem. 2011, 3(8):909-21.<\/li>\n
  52. Tuccinardi T. \u201cBinding-interaction prediction of RNA-binding ligands\u201d Future Med Chem. 2011, 3(6):723-733.<\/li>\n
  53. Ortore G, Tuccinardi T, Orlandini E, Martinelli A. \u201cDifferent Binding Modes of Structurally Diverse Ligands for Human D3DAR.\u201d J Chem Inf Model. 2010, 50(12):2162-2175.<\/li>\n
  54. Bertini S, Calderone V, Carboni I, Maffei R, Martelli A, Martinelli A, Minutolo F, Rajabi M, Testai L, Tuccinardi T, Ghidoni R, Macchia M. \u201cSynthesis of heterocycle-based analogs of resveratrol and their antitumor and vasorelaxing properties.\u201d Bioorg Med Chem. 2010, 18(18):6715-6724.<\/li>\n
  55. Rizzolio F, La Montagna R, Tuccinardi T, Russo G, Caputi M, Giordano A. \u201cAdenosine Receptor Ligands in Clinical Trials.\u201d Curr Top Med Chem. 2010; 10(10):1036-1045.<\/li>\n
  56. Chaves S, Marques SM, Matos AM, Nunes A, Gano L, Tuccinardi T, Martinelli A, Santos MA. \u201cNew Tris(hydroxypyridinones) as Iron and Aluminium Sequestering Agents: Synthesis, Complexation and In Vivo Studies.\u201d Chemistry – A European Journal 2010, 16(34):10535-10545.<\/li>\n
  57. Tuccinardi T, Botta M, Giordano A, Martinelli A. \u201cProtein Kinases: Docking and Homology Modeling Reliability.\u201d J Chem Inf Model. 2010, 50(8):1432-1441.<\/li>\n
  58. Rizzolio F, Tuccinardi T, Caligiuri I, Lucchetti C, Giordano A. \u201cCDK inhibitors: from the bench to clinical trials.\u201d Curr. Drug Targets. 2010;11(3):279-290.<\/li>\n
  59. Nuti E, Panelli L, Casalini F, Avramova SI, Orlandini E, Santamaria S, Nencetti S, Tuccinardi T, Martinelli A, Cercignani G, D\u2019Amelio N, Maiocchi A, Uggeri F, Rossello A. \u201cDesign, Synthesis, Biological Evaluation, and NMR Studies of a New Series of Arylsulfones As Selective and Potent Matrix Metalloproteinase-12 Inhibitors.\u201d J Med Chem 2009, 52(20):6347-6361.<\/li>\n
  60. Tuccinardi T, Taliani S, Bellandi M, Da Settimo F, Da Pozzo E, Martini C, Martinelli A. “A virtual screening study of the 18-kDa translocator protein using pharmacophore models combined with 3D-QSAR studies.” ChemMedChem 2009, 4(10):1686-1694.<\/li>\n
  61. Nuti E, Casalini F, Avramova SI, Santamaria S, Cercignani G, Marinelli L, La Pietra V, Novellino E, Orlandini E, Nencetti S, Tuccinardi T, Martinelli A, Lim NH, Visse R, Nagase H, Rossello A. \u201cN-O-Isopropyl Sulfonamido-Based Hydroxamates: Design, Synthesis and Biological Evaluation of Selective Matrix Metalloproteinase-13 Inhibitors as Potential Therapeutic Agents for Osteoarthritis.\u201d J Med Chem 2009, 52(15):4757\u20134773.<\/li>\n
  62. Tuccinardi T, Ortore G, Santos MA, Marques SM, Nuti E, Rossello A, Martinelli A. \u201cMultitemplate Alignment Method for the Development of a Reliable 3D-QSAR Model for the Analysis of MMP3 Inhibitors\u201d, J Chem Inf Model. 2009, 49(7):1715-1724.<\/li>\n
  63. Manera C, Saccomanni G, Adinolfi B, Benetti V, Ligresti A, Cascio M, Tuccinardi T, Lucchesi V, Martinelli A, Nieri P, Masini E, Di Marzo V, Ferrarini PL. \u201cRational Design, Synthesis and Pharmacological Properties of New 1,8-Naphthyridin-2(1H)-on-3-Carboxamide Derivatives as Highly Selective Cannabinoid-2 Receptor Agonists.\u201d J Med Chem 2009, 52(12):3644-3651.<\/li>\n
  64. Tuccinardi T. \u201cDocking-Based Virtual Screening: Recent Developments\u201d Comb. Chem. High Throughput Screen. 2009, 12(3):303-314.<\/li>\n
  65. Brizzi A, Brizzi V, Cascio MG, Corelli F, Guida F, Ligresti A, Maione S, Martinelli A, Pasquini S, Tuccinardi T, Di Marzo V. \u201cNew Resorcinol-Anandamide \u201cHybrids\u201d as Potent Cannabinoid Receptor Ligands Endowed with Antinociceptive Activity in Vivo\u201d, J Med Chem 2009, 52(8):2506-2514.<\/li>\n
  66. La Motta C, Sartini S, Tuccinardi T, Nerini E, Da Settimo F, Martinelli A. \u201cComputational Studies of Epidermal Growth Factor Receptor: Docking Reliability, Three-Dimensional Quantitative Structure\u2212Activity Relationship Analysis, and Virtual Screening Studies\u201d, J Med Chem 2009, 52(4):964-975.<\/li>\n
  67. Minutolo F, Bertini S, Granchi C, Marchitiello T, Prota G, Rapposelli S, Tuccinardi T, Martinelli A, Gunther J R, Carlson K E, Katzenellenbogen J A, Macchia M. \u201cStructural Evolutions of Salicylaldoximes as Selective Agonists for Estrogen Receptor Beta\u201d, J Med Chem 2009, 52(3):858-867.<\/li>\n
  68. Marques SM, Nuti E, Rossello A, Supuran CT, Tuccinardi T, Martinelli A, Santos MA. \u201cDual Inhibitors of Matrix Metalloproteinases and Carbonic Anhydrases: Iminodiacetyl-Based Hydroxamate\u2212Benzenesulfonamide Conjugates.\u201d J Med Chem 2008, 51(24):7968-7979.<\/li>\n
  69. Cincinelli R, Cassinelli G, Dallavalle S, Lanzi C, Merlini L, Botta M, Tuccinardi T, Martinelli A, Penco S, Zunino F. \u201cSynthesis, modeling and RET protein kinase inhibitory activity of 3- and 4-substituted-\u03b2-carbolin-1-ones.\u201d J Med Chem 2008, 51(24):7777-7787.<\/li>\n
  70. Baraldi PG, Preti D, Tabrizi MA, Romagnoli R, Saponaro G, Baraldi S, Botta M, Bernardini C, Tafi A, Tuccinardi T, Martinelli A, Varani K, Borea PA. \u201cStructure-Activity Relationship Studies of a New Series of Imidazo[2,1-f]purinones as Potent and Selective A3 Adenosine Receptor Antagonists\u201d Bioorg Med Chem 2008, 16(24):10281-10294.<\/li>\n
  71. Tuccinardi T, Nuti E, Ortore G, Rossello A, Avramova SI, Martinelli A. \u201cDevelopment of a receptor-based 3D-QSAR study for the analysis of MMP2, MMP3, and MMP9 inhibitors\u201d, Bioorg Med Chem 2008, 16(16):7749-7758.<\/li>\n
  72. Manera C, Tuccinardi T, Martinelli A. \u201cIndoles and related compounds as cannabinoid ligands\u201d Mini rev. Med. Chem. 2008, 8(4):370-387.<\/li>\n
  73. Tuccinardi T, Schenone S, Bondavalli F, Brullo C, Bruno O, Ranise A, Zizzari A, Tintori C, Ciampi O, Trincavelli ML, Martini C, Martinelli A, Botta M. \u201cSubstituted Pyrazolo[3,4-b]pyridines as potent and selective A1 adenosine antagonists: synthesis, biological evaluation and development of an A1 bovine receptor model\u201d, ChemMedChem 2008, 3(6):898-913.<\/li>\n
  74. Rapposelli S, Cuboni S, Digiacomo M, Lapucci A, Trincavelli ML, Tuccinardi T, Balsamo A. \u201cSynthesis and AT1 affinity evaluation of benzamidophenyl analogs of known AT1 receptor ligands with similar aromatic skeleton\u201d, Arkivoc 2008, (ii) 268-286.<\/li>\n
  75. Martinelli A, Tuccinardi T. \u201cMolecular modeling of adenosine receptors: new results and trends\u201d Med. Res. Rev. 2008 28(2):247-277.<\/li>\n
  76. Cosimelli B, Greco G, Ehlardo M, Novellino E, Da Settimo F, Taliani S, La Motta C, Bellandi M, Tuccinardi T, Martinelli A, Ciampi O, Trincavelli ML, Martini C. \u201cDerivatives of 4-Amino-6-hydroxy-2-mercaptopyrimidine (AHMP) as Novel, Potent, and Selective A3 Adenosine Receptor Antagonists\u201d J Med Chem. 2008, 51(6):1764-1770.<\/li>\n
  77. Minutolo F, Bellini R, Bertini S, Carboni Isabella, Lapucci A, Pistolesi L, Prota G, Rapposelli S, Solati F, Tuccinardi T, Martinelli A, Stossi F, Carlson K, Katzenellenbogen B, Katzenellenbogen J, Macchia M. \u201cMonoaryl-substituted Salicylaldoximes as Ligands for Estrogen Receptor Beta\u201d J Med Chem. 2008, 51(5):1344-1351.<\/li>\n
  78. Tuccinardi T, Ortore G, Supuran CT, Rossello A, Martinelli A. \u201cHomology Modelling and Receptor-Based 3D-QSAR study of Carbonic Anhydrase IX\u201d, J Chem Inf Mod. 2007, 47(6):2253-2262.<\/li>\n
  79. Da Settimo F, Primofiore G, Taliani S, Marini AM, La Motta C, Simorini F, Salerno S, Sergianni V, Tuccinardi T, Martinelli A, Cosimelli B, Greco G, Novellino E, Trincavelli ML, Martini C. \u201c5-Amino-2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one: A Versatile Scaffold to Obtain Potent and Selective A3 Adenosine Receptor Antagonists\u201d, J Med Chem. 2007, 50(23):5676-5684.<\/li>\n
  80. Tuccinardi T, Martinelli A. \u201cComputational Approaches on Angiotensin Receptors and their Ligands: Recent Developments and Results\u201d Curr. Med. Chem. 2007, 14(29):3105-3121.<\/li>\n
  81. Manera C, Cascio MG, Benetti V, Allar\u00e0 M, Tuccinardi T, Martinelli A, Saccomanni G, Vivoli E, Ghelardini C, Di Marzo V, Ferrarini PL. \u201cNew 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists\u201d Bioorg Med Chem Lett. 2007, 17(23):6505-6510.<\/li>\n
  82. Brizzi A, Brizzi V, Martinelli A, Tuccinardi T, Cascio MG, Bisogno T, Di Marzo V. \u201cDesign, Synthesis and binding studies of new potent ligands of cannabinoid receptor (II)\u201d, Bioorg Med Chem. 2007, 15(16):5406-5416.<\/li>\n
  83. Tuccinardi T, Manetti F, Schenone S, Martinelli A, Botta M. \u201cConstruction and Validation of a RET TK Catalytic Domain by Homology Modeling\u201d, J Chem Inf Mod. 2007 47(2):644-655.<\/li>\n
  84. Nuti E, Tuccinardi T, Rossello A. \u201cMatrix Metalloproteinase Inhibitors: New Challenges in the Era of Post Broad-Spectrum Inhibitors\u201d Curr. Pharm. Design. 2007, 13(20):2087-2100.<\/li>\n
  85. Tuccinardi T, Nuti E, Ortore G, Supuran CT, Rossello A, Martinelli A. \u201cAnalysis of human Carbonic Anhydrase II: Docking Reliability and Receptor-Based 3D-QSAR study\u201d, J Chem Inf Mod. 2007 47(2):515-525.<\/li>\n
  86. Tuccinardi T, Cascio MG, Di Marzo V, Manera C, Ortore G, Saccomanni G, Martinelli A. \u201cStructure-Based Virtual screening: Identification of novel CB2 receptor ligands\u201d, LDDD. 2007, 4(1):15-19.<\/li>\n
  87. Santos AM, Marques SM, Tuccinardi T, Carelli P, Panelli L, Rossello A. \u201cDesign, Synthesis And Molecular Modeling Study Of Iminodiacetyl Monohydroxamic Acid Derivatives As Mmp Inhibitors\u201d, Bioorg Med Chem. 2006, 14(22):7539-7550.<\/li>\n
  88. Manera C, Benetti V, Castelli MP, Cavallini T, Lazzarotti S, Pibiri F, Saccomanni G, Tuccinardi T, Vannacci A, Martinelli A, Ferrarini PL. \u201cDesign, synthesis and biological evaluation of new 1,8-naphthyridin-4(1H)-on-3-carboxamide and quinolin-4(1H)-on-3-carboxamide derivatives as CB2 selective agonists\u201d, J Med Chem. 2006, 49(16):5947-5957.<\/li>\n
  89. Tuccinardi T, Bertini S, Martinelli A, Minutolo F, Ortore G, Placanica G, Prota G, Rapposelli S, Carlson KE, Katzenellenbogen JA, Macchia M. \u201cSynthesis of Anthranylaldoxime Derivatives as Estrogen Receptor Ligands and Computational Prediction of Binding Modes\u201d, J Med Chem. 2006, 49(16):5001-5012.<\/li>\n
  90. Tafi A, Bernardini C, Botta M, Corelli F, Andreini M, Martinelli A, Ortore G, Baraldi PG, Fruttarolo F, Borea PA, Tuccinardi T. \u201cPharmacophore based receptor modeling: a novel approach to protein model optimization. The case of Adenosine A3 receptor antagonists\u201d, J Med Chem. 2006, 49(14):4085-4097.<\/li>\n
  91. Martinelli A, Tuccinardi T. \u201cGPCR modeling: methods and validation. An overview of recent developments\u201d Exp. Opin. on Drug Disc. 2006, 1(5):459-476.<\/li>\n
  92. Tuccinardi T, Calderone V, Rapposelli S, Martinelli A. \u201cProposal of a new binding orientation for non-peptide AT1 antagonists: homology model, docking and 3D-QSAR analysis\u201d, J Med Chem. 2006, 49(14):4305-4316.<\/li>\n
  93. Minutolo F, Bertini S, Martinelli A, Ortore G, Placanica G, Prota G, Rapposelli S, Tuccinardi T, Sheng S, Carlson KE, Katzenellenbogen BS, Katzenellenbogen JA, Macchia M. \u201cSalicylaldoximes and anthranylaldoximes as alternatives phenol-based estrogen receptor ligands\u201d, Arkivoc 2006, (viii) 83-94.<\/li>\n
  94. Tuccinardi T, Martinelli A, Nuti E, Carelli P, Balzano F, Uccello-Barretta G, Murphy G, Rossello A. \u201cAmber force field implementation, molecular modelling study, synthesis and MMP-1\/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamides\u201d, Bioorg Med Chem. 2006, 14(12):4260-4276 (cover of the Volume).<\/li>\n
  95. Tuccinardi T, Manera C, Ortore G, Saccomanni G, Martinelli A. \u201cAdenosine receptor modelling. A1\/A2a selectivity\u201d, Eur J Med Chem. 2006, 41(3):321-329.<\/li>\n
  96. Ortore G, Tuccinardi T, Bertini S, Martinelli A. \u201cA theoretical study to investigate D2DAR\/D4DAR selectivity: receptor modeling and molecular docking of dopaminergic ligands\u201d, J Med Chem. 2006, 49(4):1397-1407.<\/li>\n
  97. Tuccinardi T, Ferrarini PL, Manera C, Ortore G, Saccomanni G, Martinelli A. \u201cCannabinoid CB2\/CB1 selectivity. Receptor modelling and automated docking analysis\u201d, J Med Chem. 2006, 49(3):984-994.<\/li>\n
  98. Minutolo F, Bertini S, Betti L, Danesi R, Gervasi G, Giannaccini G, Martinelli A, Papini A, Peroni E, Placanica G, Rapposelli S, Tuccinardi T, Macchia M. \u201cSynthesis of stable analogues of geranylgeranyl diphosphate possessing a (z,e,e)-geranylgeranyl side-chain, docking analysis and biological assays for their prenyl protein transferase inhibitory activity\u201d, Chem Med Chem. 2006, 1(2):218-224.<\/li>\n
  99. Manera C, Betti L, Cavallini T, Giannaccini G, Martinelli A, Ortore G, Saccomanni G, Trincavelli L, Tuccinardi T, Ferrarini PL. \u201c1,8-Naphthyridin-4-one derivatives as new ligands of A2A adenosine receptors\u201d, Bioorg Med Chem Lett. 2005, 15(20):4604-4610.<\/li>\n
  100. Rossello A, Nuti E, Catalani MP, Carelli P, Orlandini E, Rapposelli S, Tuccinardi T, Atkinson SJ, Murphy G, Balsamo A. \u201cA new development of matrix metalloproteinase inhibitors: twin hydroxamic acids as potent inhibitors of MMPs\u201d, Bioorg Med Chem Lett. 2005, 15(9):2311-2314.<\/li>\n
  101. Ferrarini PL, Betti L, Cavallini T, Giannaccini G, Lucacchini A, Manera C, Martinelli A, Ortore G, Saccomanni G, Tuccinardi T. \u201cStudy on affinity profile toward native human and bovine adenosine receptors of a series of 1,8-naphthyridine derivatives\u201d, J Med Chem. 2004, 47(12):3019-3031.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    Poli G, Martinelli Tuccinardi T. A, \u201cReliability analysis and optimization of the consensus docking approach for the development of virtual…<\/p>\n

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